— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…
— Three yeast plasmids that express yeast genes tagged with the fluorescent mCherry protein under the control of the GAL promoter. The genes were modified to be cre-less to so the plasmids could be used to study autoregulation in yeast. pMBJ1 pMBJ1-RPL1B-cl pMBJ1-RPS22-cl Publication: Roy, B., Gr…
— This plasmid was created to test the regulatory impact of 5’ untranslated regions in yeast. It consists of EGFP under the control of the S. cerevisiae TEF2 promoter with cloning sites to modify the 5’UTR. Publication: Roy, B., Granas, D., Bragg, F., Cher, J. A., White, M. A., & Stor…
— This is a mouse knockout strain for CD26, also known as DNAM-1 (DNAX accessory molecule 1). DNAM-1 is an adhesion molecule belonging to the immunoglobulin superfamily. This mouse model was used to study the role of DNAM-1 on CD8 T cell and NK cell function in vitro and in vivo. Publication: Gilfill…
— This is a recombinant clone of the Chikungunya LR2006 virus expressing Cre recombinase inserted downstream of a subgenomic promoter. In vitro transcription and transfection of RNA derived from this plasmid into cells will result in the generation of Chikungunya virus that expresses Cre recombinase i…
— Mouse strain deficient in IL-34 production with defective Langerhans cells and microglia. These mice can be used to assess the role of the cytokine IL-34 in the development and maintenance of peripheral macrophage populations. Publication: Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossin…
— Ebola viral protein 30 (eVP30) plays a critical role in transcription initiation for viral RNA synthesis. These materials could be used to test for Ebola virus infection. Publication: Xu, W., Luthra, P., Wu, C., Batra, J., Leung, D. W., Basler, C. F., & Amarasinghe, G. K. (2017). Ebola virus VP…
— 64Cu-DOTA-vMIP-II is a broad spectrum PET imaging agent that provides a non-invasive measurement of up to 10 chemokine receptors involved in the inflammatory processes of various diseases. This agent is based on the peptide vMIP-II (viral macrophage inflammatory protein-II), a viral CC chemokine enc…
— C57BL/6 ES cells were targeted with a vector (European Conditional Mouse Mutagenesis Program) carrying loxP sites flanking exon 3 of mouse Cept1. A karyotypically normal clone (of 10 correctly targeted) was injected into B6(Cg)-Tyrc-2J/J blastocysts and chimeric mice were bred with B6(Cg)-Tyrc2J/J f…
— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…
— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…
— Technology Description: Researchers at Washington University in St. Louis have identified blood-based cytokine signatures that could be used to specifically detect, distinguish and monitor septic arthritis, synovitis and osteomyelitis. This assay could enable timely, accurate treatment to avoid joi…
— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…
— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…
— Technology Description Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…
— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…
— Technology Description This technology is a patented method aimed at increasing the success rate of atrial fibrillation (AF) treatment by designing customized, patient-specific cardiac ablation lesion sets. AF, the most common sustained cardiac arrhythmia, has traditionally been treated with a ma…
— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…
— Technology Description Researchers in Prof. Netanel Raviv’s laboratory have developed a provable error correcting code (ECC) system that could guarantee deep neural networks (DNN) are resilient to noise for robust, secure and private neural computation. This technology could be deployed in n…
