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Humanized rat model of Wolfram SyndromeUrano, Fumihiko
T-019403
— A humanized rat model of Wolfram Syndrome carrying a Wfs1 gene mutation corresponding to human WFS1 gene point mutation with a stop codon at position a.a. 452.
Elastin conditional knockout mouseWagenseil, Jessica ; Mecham, Robert
T-019289
— Mouse with floxed elastin gene to conditionally inactivate elastin gene expression. Publication: Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development
Mouse bladder cancer organoid cell line MCB6ABolzenius, Jennifer ; Arora, Vivek
T-019309
— MCB6A organoids generate urothelial tumors with features similar to the basal-squamous subtype of urothelial carcinoma, the most common bladder cancer. MCB6A harbors 1,524 mutations, including mutations in Kdm6a and Trp53. Publication: CD4+ T cells induce rejection of urothelial tumors after imm…
Plasmids for cyanobacterial CRISPRi and high sucrose productionPakrasi, Himadri
T-019345
— Plasmid for CRISPR interference in Synechococcus sp. UTEX 2973: pSL3287 (Addgene), included in publication: Tunable repression of key photosynthetic processes using Cas12a CRISPR interference in the fast-growing cyanobacterium Synechoccoccus sp. UTEX 2973 Plasmids for high level of sucrose produ…
Shuttle vectors for gene expression in E. Coli and CyanobacteriaPakrasi, Himadri
T-019193
— Two shuttle vectors, pCA-UC118 and pCB-SC101, capable of replication in both Synechocystis 6803 and E. coli. Expression of reporter proteins were significantly enhanced in cells containing these new plasmids, thus providing superior gene expression platforms in this cyanobacterium. Publication: …
UPAB1 plasmid lacking pAB5Di Venanzio, Gisela ; Feldman, Mario
T-019205
— An UPAB1 derivative, UPAB1p-, that spontaneously loss pAB5 was identified by detection of restored Hcp secretion and isolated via an ELISA. Compared to wildype UPAB1, UPAB1p- displayed comparable growth in vitro in both rich medium and urine from healthy donors, indicating that less pAB5 did not in…
Suicide plasmid pSL2231Pakrasi, Himadri
T-019201
— pSL2231 is a derivative of pBR322 that can be used to delete the nblA gene in Synechococcus UTEX 2973. Publication: Synechococcus elongatus UTEX 2973, a fast growing cyanobacterial chassis for biosynthesis using light and CO2
Irg1 conditional knockout mouseDiamond, Michael
T-019215
— Irg1−/− mice were generated after receiving embryonic stem cells (ESCs) from the Knockout Mouse Project Repository containing an insertion cassette between exons 3 and 4. This cassette prevents transcription of downstream exons 4 and 5 and production of mature protein. Irg1−/&minu…
Compound to treat alcohol use disorderMennerick, Steven ; Covey, Douglas
T-019232
— Technology Description Researchers at Washington University in St. Louis have developed new compounds that may be used to treat alcohol use disorder (AUD). AUD, a common condition that takes a high personal and public health toll, is characterized by severe problems with drinking- sufferers may co…
geOMV: Bacterial vaccine development platform using glycoengineered microbesFeldman, Mario
T-015094
— Technology Description Researchers in Prof. Mario Feldman’s laboratory have developed a patented, versatile, cost-effective platform for creating new multivalent vaccines for a variety of Gram-negative and Gram-positive bacteria. This technology, glycoengineered outer membrane vesicles (geOM…
Recombinant VSV vector for COVID-19 vaccine or drug screeningRothlauf, Paul ; Whelan, Sean
T-019338
— Background: Recombinant vesicular stomatitis virus (VSV) has successfully been used to create a vaccine for Ebola virus that is currently on the market. Previously, Professor Sean Whelan and colleagues have exploited the VSV platform to create similar vectors for both SARS and MERS. Technology: The…
PANIR: Photoacoustic near-infrared spectroscopy for monitoring preterm birthTuuli, Methodius ; Zhao, Peinan ; Macones, George ; Stout, Molly ; Hu, Peng ; Qu, Yuan "Ed"
T-018998
— Technology Description An interdisciplinary team of researchers has developed a photoacoustic near-infrared (PANIR) probe to predict preterm birth by quantifying water content in cervical tissue (an early and objective indicator of cervical remodeling). This compact photoacoustic endoscopy probe u…
LDLRAD3 KO miceThackray, Larissa ; Diamond, Michael
T-019372
— Venezuelan equine encephalitis virus (VEEV) is an emerging infectious disease in South America transmitted by mosquitos. VEEV usually resides in forest and swamp areas where human populations are limited, however, VEEV has the potential to cause epidemics in humans and equines. LDLRAD3 has been foun…
Bacterial and Mammalian Expression Vectors for Production of SARS-CoV ProteinsNelson, Christopher ; Zhao, Haiyan ; Harvey, Ian ; Dai, Yanan ; Fremont, Daved
T-019413
— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available. Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…
Ceramide profiling for blood-based predictive screening for cardiovascular disease, heart failure and deathPeterson, Linda ; Ory, Daniel ; Schaffer, Jean
T-014627
— Technology Description A team of researchers has developed a high throughput, FDA-compliant assay to predict coronary heart disease and mortality in the general population 6-10 years before the onset of disease. This fully validated two-dimensional liquid chromatography-tandem mass spectrometry (L…
Method to generate functionally mature, stem-cell derived, beta cellsVelazco-Cruz, Leonardo ; Millman, Jeffrey
T-019270
— Technology Description Researchers at Washington University in St. Louis have developed an improved method to differentiate stem-cells into functionally mature, insulin-secreting beta cells (SC-beta cells). Pancreatic beta cells play an important role in controlling blood glucose levels as they se…
miRNA mimics to treat metabolic diseaseGong, Yong-feng ; Hou, Jianghui
T-017930
— Disease indication: metabolic disorders including insulin resistance and diabetic nephropathy Drug format: chemically modified synthetic microRNA (miRNA) Drug class: first-in-class for metabolic disease Research stage and Preliminary data: Target: miR-29 mimics can increase the gene expressio…
Rapid PEG-based drug delivery implant for local treatment of cervical cancerSun, Jennifer ; Schwarz, Julie ; Federico, Cinzia ; Azab, Abdel Kareem
T-019396
— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors. The current standard-of-care treatment regimen …
Mouse monoclonal antibodies against SARS-CoV-2 spike proteinVanBlargan, Laura ; Zhao, Haiyan ; Fremont, Daved ; Diamond, Michael
T-019470
— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…
Human monoclonal antibodies against SARS-CoV-2 spike proteinTurner, Jackson ; Mudd, Philip ; Schmitz, Aaron ; McIntire, Katherine ; Ellebedy, Ali
T-019454
— Species: Human Target: SARS-CoV-2 spike protein Applications: Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab Available Antibodies mAb name Ag 30.0000 10.0…
