Chemicals Summaries

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

Novel benzo crown-ethers to create synthetic ion channels
Carrasquel Ursulaez, Willy ; Chanda, Baron
T-019832

— Technology Description Researchers in Baron Chanda’s lab at Washington University and Jennifer Schomaker’s lab at University of Wisconsin-Madison have developed a library of benzo(crown-ether) compounds capable of self-assembly into ion channels. These monoacylated and monoalkylated be…

High-speed perovskite LED fabrication by inkjet printing
Wang, Chuan ; Zhao, Junyi
T-019910

— Technology Description Researchers in Chuan Wang’s lab at Washington University have developed a method of fabricating perovskite LEDs (PeLEDs) directly on an elastic substrate more than 10X faster than existing methods. Each layer of the PeLED is patterned using a highly scalable inkjet pri…

Passive and Compact Liquid Metal Heat Switch
Weisensee, Patricia
T-019180

— Technology Description Researchers in Patricia Weisensee’s lab at Washington University have developed a compact liquid metal heat switch with a passive mechanism to control the thermal management system of spacecraft. Unlike other switch mechanisms, the liquid metal version produces high co…

Sustainable rare earth element extraction from coal ash
Jun, Young-Shin ; Zhu, Yaguang
T-019257

— Technology Description Researchers in Young-Shin Jun’s lab at Washington University have developed a more sustainable and efficient process for extracting rare earth elements from coal fly ash using supercritical fluids. Compared to the conventional roasting and acid leaching method, supercr…

Photothermal disinfection of N95 respirators
Jun, Young-Shin ; Singamaneni, Srikanth
T-019477

— Technology Description A team of researchers led by Young-Shin Jun have developed a polymer coating for N95 respirators that would permit fast, easy, and cheap N95 disinfection using only direct sunlight. The researchers coated the outermost fabric layer in polydopamine, which converts photon energ…

Encapsulation to protect detection antibodies in implantable and wearable biosensors
Chakrabartty, Shantanu ; Gupta, Rohit ; Luan, Jingyi ; Morrissey, Jeremiah ; Scheller, Erica ; Singamaneni, Srikanth
T-019364

— Technology Description An interdisciplinary team of researchers at Washington University have developed a universal system designed to extend the lifetime of implantable and wearable biosensors by protecting detection antibodies from harsh conditions and enabling a refreshing process to release bo…

Low-cost, high-performance materials for solar-driven membrane distillation in water treatment and desalination
Jiang, Qisheng ; Jun, Young-Shin ; Singamaneni, Srikanth ; Wu, Xuanhao
T-019047

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory and Prof. Singamaneni’s laboratory have developed high performance, stable membrane materials that can be used for photothermal membrane distillation (PMD) to purify or desalinate water with minimal input of electric…

Scalable synthesis of stable, highly conductive, solution-processable PEDOT particles for organic electronics
D'Arcy, Julio M. ; Lu, Yang
T-019278

— Technology Description Researchers in Prof. Julio D’arcy’s laboratory have developed aerosol vapor polymerization (AVP), a scalable continuous batch-processing platform to produce bulk quantities of stable submicron conductive particles for organic electronics. Unlike traditional PEDOT…

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Low-cost, single-step vapor deposition of thin film organic perovskites for solar and memristor applications
Banerjee, Parag ; Chen, Xiao ; Myung, Yoon
T-017124

— Technology Description Engineers in the Banerjee laboratory have developed a single-step, scalable vapor deposition process for fabricating high performance thin film perovskite materials at low temperature and atmospheric pressure. These lead-free, non-toxic films could be used as solar cell abso…

Low cost electrode decoupled redox flow batteries for grid-scale energy storage
Ramani, Vijay ; Sankarasubramanian, Shrihari
T-018530

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed an electrode decoupled redox flow battery (RFB) with stable electrolyte materials that can generate power densities comparable to all-Vanadium RFBs at less than half the cost. RFBs are a promising option for …

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Low cost, high performance anion exchange membranes for grid-scale energy storage and other electrochemical devices
Parrondo, Javier ; Ramani, Vijay ; Wang, Zhongyang
T-018608

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a variety of robust, versatile anion exchange membrane (AEM) materials that achieve high performance through superior ion selectivity. These mechanically and chemically stable membranes have the potential to d…

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

SPECT imaging nanoprobe for the detection of matrix metalloproteinase (MMP) activity
Achilefu, Samuel ; Black, Kvar
T-014635

— This invention is the formulation of a SPECT nanoparticle probe for the detection of MMP activity. The surface of a 10 nm-sized gold nanoparticle is functionalized through a thiol anchor with a peptide that is cleaved in the presence of MMP9. The surface is also functionalized with methoxy polyethyl…

Nanocomposite fertilizer for efficient phosphorus uptake and sustainable agriculture
Biswas, Pratim ; Raliya, Ramesh
T-016378

— Technology Description Engineers in Prof. Pratim Biswas’ laboratory have developed a nanoparticle fertilizer that increases phosphorus uptake and plant yield while reducing environmental damage and strain on natural resources. Increasing global food demand has prompted the large-scale use o…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-017288

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Novel benzo crown-ethers to create synthetic ion channels
Carrasquel Ursulaez, Willy ; Chanda, Baron
T-019832

— Technology Description Researchers in Baron Chanda’s lab at Washington University and Jennifer Schomaker’s lab at University of Wisconsin-Madison have developed a library of benzo(crown-ether) compounds capable of self-assembly into ion channels. These monoacylated and monoalkylated be…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-017288

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Selective RANK ligand to treat osteoporosis
Fremont, Daved ; Nelson, Christopher ; Teitelbaum, Steven ; Warren, Julia
T-014404

— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…

Hydrogel substrate system with easy, robust protein functionalization for cell culture
Pathak, Amit ; Sarker, Bapi
T-018649

— Technology Description Researchers in Prof. Amit Pathak’s laboratory have developed a hydrogel system that utilizes an aldehyde-based compound to easily and reliably pre-functionalize polyacrylamide for conjugation of proteins, such as collagen and fibronectin, for cell culture applications.…

High Throughput Acoustic Particle Separation
Berezin, Mikhail ; Binkley, Michael ; Meacham, John
T-017364

— Technology Description: Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices. Applications: 1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…

Itaconate Immunomodulatory Properties-Ischemia Reperfusion
Artyomov, Maxim ; Lampropoulou, Vasiliki "Vicky"
T-016181

— Technology Summary: Approximately 1.3 million individuals each year in USA alone are affected by ischemia-reperfusion injuries. A substantial portion of such injuries is the result of macrophage-mediated inflammation. There are some conventional methods for treating macrophage-mediated inflammation,…

Hydrogel substrate system with easy, robust protein functionalization for cell culture
Pathak, Amit ; Sarker, Bapi
T-018649

— Technology Description Researchers in Prof. Amit Pathak’s laboratory have developed a hydrogel system that utilizes an aldehyde-based compound to easily and reliably pre-functionalize polyacrylamide for conjugation of proteins, such as collagen and fibronectin, for cell culture applications.…

Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-016665

— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

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