Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB and MSA. Determining the level and distribution of aggregated alpha-synuclein could be useful for early diagnosis and for monitoring response to therapy in these diseases. They could also potentially be useful for treatment of Parkinson Disease and related diseases.
Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Tech ID: T-014558