Office of Technology Management/Tech Transfer

WASHU INNOVATION CATALOG

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human SIRP-B2

by | Nov 13, 2019 | Colonna, Marco

— Target: Cluster of Differentiation 172g protein, a.k.a. Signal Regulatory Protein Beta-2.

Notes: Clone name is LSB2.20.

Monoclonal antibodies were raised in a 4-to 8 week-old female Balb/c mouse by immunozation with a recombinant GST fusion protein containing the whole extracellular domain of SIRPB1. These can be used to study T-cell activation and the induction of antigen-specific cytotoxic T-lymphocyte responses by…

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD155 (PVR)

by | Nov 7, 2019 | Colonna, Marco

— Target: CD155 is a adhesion receptor, orginally known as the cellular receptor for Polio Virus.

Notes: Clone name is SK II 4.3

Information on antibody against poliovirus receptor (CD155)

Herein, we describe the generation of a murine antibody that recognizes poliovirus receptor (CD155). We made this antibody by immunizing mice with SK-N-S1 human neuroblastoma cells. We then validated this antibody using flow cytometry.

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Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD96 (Tactile)

by | Nov 6, 2019 | Colonna, Marco

— Target: CD96 is a T cell-specific receptor indicative of T cell activation.

Notes: Clone name NK92.39.1. For use in flow cytometry.

Researchers generated the antibodies by immunizing mice with NK92 cells and selected hybridomas that plocked binding of PVR to NK92. These antibodies have been used to study natural killer cell target cell adhesion.

Publication: Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by …

Armenian hamster anti-mouse TCR Vb 8.3 IgG3 monoclonal antibody (clone 1B3.3)

by | Nov 6, 2019 | Allen, Paul

— Target: Full length mouse Vb 8.3 TCR but not 8.1 or 8.2. Vb 8.3.

Application: Flow cytometry

This antibody was made by immunizing Armenian hamsters. It was used to study the mechanisms that act to keep only one functional TCR beta-chain per cell and the effect of selecting ligand density on positive selection and endogenous receptor usage in mice.

Publication: TCR transgenic mice in which …

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