Fibroblast-Derived Cell Line Producing Wnt3a, R-spondin 3, & Noggin

— Tangible Tool: Growth factor over-expressing cell line.

Notes: Produces conditioned media to grow various mammalian tissue stem cells.

These supportive L-WRN cells can produce conditioned media containing Wnt3a, R-spondin, and Noggin for the the support of gastrointestinal stem cells. This system can be used to make stem cell enriched epithelial spheroids from the mouse gastrointestine.

Publication: In vitro expansion and genetic…

cryaa-R49C knock-in mice

— Knock-in mice with a mutation in alpha-crystallin (cryaa-R49C) that causes cataracts. A knock-in plasmid was generated by cloning the 5′ and 3′ arms of the mouse RAcrystallin gene, followed by mutation and homologous recombination in mouse embryonic stem cells, which were implanted into …

scFv-TR3: TRAIL trimers targeted to mesothelin

— WUSTL Technology 016481

Technology Description

Researchers at Washington University in St. Louis have developed an additional targeting strategy to provide more flexibility and improve the bioactivity of the anticancer therapeutic TR3. This strategy targets TR3 to mesothelin, a tumor biomarker fr…

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