— Technology Description
Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…
— Disease indications:
Drug format: small molecule
Drug class: first in class
Research stage and Preliminary data:
Preclinical development of the lead compound for respiratory disease includes in vitro and in vivo efficacy, selectivity and initial toxicity testing. Preclinical development of the…
— Background: Niemann-Pick type C1 (NPC1) disease is a rare neurological disorder characterized by cholesterol and lipid accumulation in the central nervous system. Individuals with the abnormal buildup of cholesterol and other lipids in the brain often suffer from cognitive and movement difficulties,…
— Background
Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease.
Technology Summary
Pharmacological or genetic activation of the Arginine…
— This features an enzymatic function for a protein so that Washington University can obtain composition of matter rights and use rights for screening for inhibitors. This can be used for weight loss, diabetes, treatment of obesity and associated lipotoxicity, body sculpting, heart disease, stroke a…
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Creating...
