Plasmid pHLFcHis-Glycophorin A
— Plasmid comprising the signal peptide and extracellular domain of human glycophorin A fused to antibody Fc domain and a his tag. This plasmid has been used to study malaria treatments.
Publications:
Six2-GFP reporter iPSC line (subject to GE – GFP license)
— Researchers used CRISPR/Cas9-mediated gene targeting to knock in a GFP-P2A cassette into the ATG of the Six2 gene in human BJFF.6 induced pluripotent stem cells. The cells exhibit GFP expression in Six2+ cells when induced to differentiate towards the renal lineage. Six2 expression marks a progenito…
ABCA3-GFP expression constructs
— This technology includes a plasmid with the full length ATP-binding cassette transporter A3 (ABCA3) cDNA cloned into the pAcGFP1-N1 vector and another plasmid with the ABCA3-GFP cDNA inserted into the pShuttle vector. Mutations in ABCA3 lead to severe neonatal respiratory distress syndrome and child…
IRF8 +32 KO mice
— Researchers first identified and then used CRISPR to delete an enhancer located at +32 kb of the Irf8 transcriptional start site in mice. Knocking out this enhancer revealed that interferon regulatory factor 8 (IRF8) is required for the development of classical type 1 dendritic cells (cDC1s) but not…
Mpc2 floxed mice
— Using embryonic stem cells from the European knockout mouse consortium (EUCOMM), researchers developed transgenic mice with loxP sites flanking exon 3 of the mitochondrial pyruvate carrier 2 (Mpc2) gene. MPC2 is a component of the MPC complex, which is involved in the transport of pyruvate across th…
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