Cd40lg-Cre mouse
— Cd40lg-Cre mouse
Antibiotic-sparing small molecule therapy for urinary tract infection and other Gram-negative pathogens
— Technology Description
Researchers in Prof. Scott Hultgren’s laboratory have discovered an antibiotic-sparing method for treating infections from E. coli and other Gram-negative bacteria. This approach is designed to block pathogens from colonizing their host by using small molecule inhibito…
Dnmt3b transgenic mice
— Description: Dnmt3b transgenic mouse contains a full-length Flag-tagged murine Dnmt3b cDNA which is under the control of a rtTA promoter. The Dnmt3b transgenic mouse will provide both cell specific and temporal regulation for Dnmt3b over-expression upon recombination with addition of doxycycline (D…
Epigenetic drug targets to treat or prevent osteoarthritis and cartilage degradation
— A team of researchers at Washington University in St. Louis has identified an epigenetic pathway and two therapeutic targets that could be used to prevent cartilage loss and counteract the mechanism underlying osteoarthritis. The inventors have seen promising results in a mouse model of arthritis us…
Radium Chelation For Targeted Alpha Particle Therapy
— Technology Description
Researchers at Washington University in St. Louis have developed a method to chelate radium-223 and increase its utility in targeted alpha-particle therapy (TAT). TAT aims to deliver cytotoxic alpha-particles to cancer cells. Radium-223 is an alpha particle emitting isotope …
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