by | Mar 8, 2024 | Amarasinghe, Gaya, Ganaie, Safder, Leung, Daisy, Virgin, Herbert
— T-019577 – Lrp1 and the blood brain barrier
Technology Description
Researchers in Gaya Amarasinghe’s laboratory at Washington University have engineered new protein fragments (RVFV Gn) to target LRP1, which was recently identified as an essential entry factor for Rift Valley Fever Virus (RVF…
by | Feb 16, 2024 | Kotzbauer, Paul, Qiu, Lin, Tu, Zhude "Will", Yu, Yanbo
— Radiotracers to detect early Parkinson’s disease
Technology Description
Researchers at Washington University in St. Louis, led by Dr. Zhude Tu, have developed two imaging agents for α-synuclein (α-syn) aggregation for use to diagnose early Parkinson’s disease, track dise…
by | Dec 6, 2023 | Heo, Gyu Seong, Liu, Yongjian, Zhang, Xiuli
— T-020196 CD163 Targeting Agent for Imaging and Therapy
Technology Description
Researchers in Yongjian Liu’s laboratory at Washington University have synthesized a new peptide-based CD163 radiotracer. CD163 is a well-known biomarker specific to macrophages implicated in multiple diseases, but…
by | Nov 16, 2023 | Satham, Lakshminarayana, Sharma, Vijay, Sivapackiam, Jothilingam
— T-020300 PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen Species
Technology Description
Reactive Oxygen Species (ROS) is known to contribute to the pathogenesis of neuropathological conditions such as Alzheimer’s disease and cancer. However, there&…
by | Nov 16, 2023 | Sharma, Vijay, Sivapackiam, Jothilingam
— T-019479 Tissue-penetrating PET radiotracer for non-invasive detection of ROS and inflammation.
Technology Description
18F-fluorodeoxyglucose (18F-FDG) has long been used for the diagnosis of neoplasms, and recently Alzheimer’s disease. However, 18F-FDG signals are often not correlated with…