by | Mar 10, 2018 | Achilefu, Samuel, Berezin, Mikhail, Zhang, Zongren
— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…
by | Mar 10, 2018 | Achilefu, Samuel, Akers, Walter, Bauer, Adam, Culver, Joseph, Liu, Yang
— Background: Current cancer management faces several challenges, including high occurrence of residual tumor after resection, adverse effects from sentinel lymph node (SLN) biopsy, and use of bulky systems in surgical suites for image guidance.
Technology Description: To overcome these limitations, …
by | Mar 10, 2018 | Mach, Robert, Rowland, Douglas, Tu, Zhude "Will", Welch, Michael
— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …
by | Mar 10, 2018 | Conradi, Mark, Sukstansky, Alexander, Yablonskiy, Dmitriy
— Magnetic Resonance (MR) is known to allow quantitative measurements of molecular diffusion in different materials. Such materials are frequently composed of structural units. Boundaries of these units serve as restrictive barriers for diffusing molecules. In case of structurally anisotropic units,…
by | Mar 10, 2018 | Achilefu, Samuel, Berezin, Mikhail, Zhang, Zongren
— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…