by | Apr 27, 2022 | Chang, Ju Fang, Singh, Nathan
— Technology Description
Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …
by | Apr 27, 2022 | Chang, Ju Fang, Singh, Nathan
— Technology Description
Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …
by | Apr 13, 2022 | Colonna, Marco, Secca da Silva, Cristiane
— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease)
Drug format – Monoclonal antibody
Drug class – First-in-class
Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…
by | Mar 30, 2022 | Gelman, Andrew, Puyo, Carlos
— Technology Description
Researchers at Washington University in St. Louis have developed a drug combination that can be used to prevent tissue injury resulting from placement of a variety of medical devices including, but not limited to, endotracheal tubes (ETTs) and catheters (bladder catheters). P…
by | Mar 10, 2022 | DiPersio, John, Persaud, Stephen "Steve"
— Technology Description
Researchers at Washington University in St. Louis have developed an improved process for conditioning patients for allogeneic hematopoietic stem cell transplantation (alloHSCT) using JAK inhibitors. Commonly used to treat autoimmune diseases like rheumatoid arthritis, JAK inh…