by | May 5, 2020 | Mach, Robert, Tu, Zhude "Will", Wang, Wei
— Technology Description
Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…
by | Apr 30, 2020 | Chung, Charles, Kovacs, Sandor, Shmuylovich, Leonid
— Technology Description
Researchers in Prof. Sandor Kovacs’ laboratory developed a patented, non-invasive, load-independent method to measure the intrinsic diastolic performance of the heart. This load-independent index of filling (LIIF) can be incorporated into the software of echocardiogram…
by | Apr 29, 2020 | Bach, Richard, Boyle, Walter
— Background: Cardiovascular disease, including acute myocardial injury (AMI), is responsible for over 610,000 deaths per year in the US making it the number one cause of death. The gold standard for AMI diagnosis relies on determination of the cardiac troponin I (cTnI) plasma level. The rise in the l…
by | Apr 27, 2020 | Cruchaga, Carlos, Dube, Umber, Ibanez, Laura
— Technology Description:
Researchers in Prof. Carlos Cruchaga’s laboratory have identified a sensitive and specific panel of circular RNAs (circRNA) that could be used for diagnosing, screening or monitoring patients with Alzheimer’s disease. The expression of these circRNAs tracks with …
by | Apr 16, 2020 | Guilak, Farshid
— Technology Description
Researchers at Washington University in St. Louis have developed a method to create designer stem cells which provide a safer, more effective cell therapy approach to treating disease. Cell-based regenerative therapies could potentially be used to treat many diseases and res…