by | Jul 1, 2022 | Shenoy, Surendra
— Technology Description
Researchers at Washington University in St. Louis have developed a technique for arteriovenous fistula creation that reduces the incidence of juxta-anastomotic stenosis, which often leads to graft failure. The procedure involves clamping closed one end of the graft and attac…
by | Jun 28, 2022 | Klein, Robyn, Williams, Jessica
— Technology Description
Researchers in Prof. Robyn Klein’s laboratory have discovered that interferon lambda (IFN-λ) is a potential target for treating multiple sclerosis (MS), particularly secondary progressive MS (SPMS).
Most patients with MS present with relapsing remitting MS (RRM…
by | Jun 17, 2022 | Bowman, Brittany, Dolle, Roland "Ron", Lapak, Kyle, Major, Michael "Ben", Medcalf, Matthew
— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection
Drug format – Small molecule
Drug class – Best-in-class
Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…
by | Jun 2, 2022 | Guan, Jianjun, Guan, Ya, Niu, Hong
— Technology Description
Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …
by | Apr 27, 2022 | Chang, Ju Fang, Singh, Nathan
— Technology Description
Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …