by | Oct 22, 2019 | Guruswami, Sundaram, Sharma, Vijay, Sivapackiam, Jothilingam
— Background
Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…
by | Oct 22, 2019 | Berezin, Mikhail, Binkley, Michael, Meacham, John
— Technology Description:
Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices.
Applications:
1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…
by | Oct 22, 2019 | Xu, Mai
— Background: In the US alone, 154,000 new cases of colorectal cancer (CRC) are diagnosed each year. Unfortunately, a third of those patients will die due to diagnosis at late stages – the 5-year survival rate is 11%, compared to 91% for those who are diagnosed with only localized CRC. A colonos…
by | Oct 22, 2019 | Colonna, Marco, Ulland, Tyler
— Background: Alzheimer’s disease (AD) is the 6th leading cause of death in the United States, and yet causation of the disease is poorly understood and targets for therapeutic intervention are still being identified. Recently, mutations in the immune receptor TREM2 have been found to be strongl…
by | Oct 22, 2019 | Jin, Hongjun, Liu, Hui, Luo, Zonghua, Tu, Zhude "Will"
— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…