by | Oct 28, 2024 | Dolle, Roland "Ron", Zhou, Mingzhou
— Value Proposition: Small molecule Gastrin-releasing peptide receptor (GRPR) antagonists used to treat chronic itch.
Technology Description
Researchers at Washington University in St. Louis have discovered a group of small molecule Gastrin-releasing peptide receptor (GRPR) antagonists to treat c…
by | Jul 24, 2024 | Barratt, Michael, Chang, Hao-Wei, Gordon, Jeffrey, Hibberd, Matthew, Wang, Yi, Webber, Daniel
— Value Proposition: Human microbe strains with robust colonization efficacy and potent in vivo harvesting of beneficial metabolites involved in infant health.
Technology Description
Researchers from the laboratory of Dr. Jeffrey Gordon at Washington University in St. Louis have discovered str…
by | Jun 2, 2022 | Guan, Jianjun, Guan, Ya, Niu, Hong
— Technology Description
Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …
by | Mar 2, 2022 | Lim, Kian-Huat, Liu, Yongjian, Zhang, Xiaohui
— Disease indication –
Drug format – Combination containing radiolabeled copper nanocluster, small molecule, and peptide
Drug class – First-in-class
Target – CCR2, the receptor for CCL2
Mode of action – The ECL1i peptide is conjugated to a copper nanocluster loaded…
by | Feb 16, 2022 | Azab, Abdel Kareem, Federico, Cinzia
— Technology Description
Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…