by | Jun 26, 2020 | Azab, Abdel Kareem, Federico, Cinzia, Schwarz, Julie, Sun, Jennifer
— Technology Description
Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors.
The current standard-of-care treatment regimen …
by | Jan 6, 2020 | Klechevsky, Eynav, Pathak, Amit, Sarker, Bapi
— Technology Description:
A team led by Drs. Amit Pathak and Eynav Klechevsky have developed a soft alginate-gelatin matrix-based synthetic dendritic cell to rapidly expand and deliver CD8+ T cells for cancer immunotherapy. CD8+ T cells kill tumors, but current methods to expand them also activate r…
by | Oct 22, 2019 | Chen, Hong, Williamson, Jeffrey, Yang, Yaoheng "Mack"
— Technology Description
Researchers in Prof. Hong Chen’s laboratory have developed a safe, convenient monitoring technique to precisely deliver drugs to the brain by integrating ultrasound imaging with ultrasound therapy (focused ultrasound-blood-brain-barrier delivery, “FUS-BBBD”…
by | Mar 10, 2018 | Lanza, Gregory, Pan, Dipanjan, Wickline, Samuel
— Background: Targeted nanoparticles have been shown to have high potential in the detection and characterization of various pathologies based on unique profiles of cell surface markers, as well as the delivery of therapeutic compounds. Liposomes, micelles, emulsions and other lipid-based particles ha…
by | Mar 10, 2018 | Hallahan, Dennis
— Technology: GRP78 is a chaperone that is part of a complex that controls the maturation of glycoproteins in the ER and senses cellular stress in normal cells. However, following radiation treatment, GRP78 is also expressed on the surface of cancer cells and has anti-apoptotic and pro-angiogenesis ac…