— Disease indication – Cancer
Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy
Drug class – Improvement
Research stage and Preliminary data:
Target – Carbohydrate biomarkers of cancer
Background:
Dendritic cells (DCs) are potent antigen presenting cell…
— Technology Description
A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics.
The virus (…
— Background
Niemann-Pick type C is a rare, progressive neurodegenerative disease characterized by accumulation of cholesterol and other lipids in the viscera and central nervous system. For cases caused by mutations in the NPC1 or NPC2 gene, egress of lipids from endosomes or lysosomes are impaired, resulting in clinical symptoms such as abnormal eye movements, hearing loss, cerebellar ataxia, difficulty swallowing, and cognitive impairment. However, patients with Neimann-Pick disease have highly variable clinical presentation and symptom progression, making diagnosis challenging.
Technology Summary
A panel of oxygenated forms of cholesterol (oxysterols) in plasma that can be used as a diagnostic test for Neimann-Pick type C1 disease. The mass spectrometry-based panel is able to discriminate between subjects with NPC1 and normal control subjects. The oxysterol biomarkers have clinical utility in newborn screening for early diagnosis of NP1C disease, as markers for disease severity, and as biomarkers to aid in evaluation of new therapies for NPC1.
Key Advantages
High sensitivity
Rapid diagnostic for screening infants
Patents
US 8,497,122 Issued
US 9,012,216 Issued
Publications
Porter et al., 2010 – Cholesterol oxidation products are sensitive and specific blood-based biomarkers for NPC1 disease.
— Technology Description
Researchers in Prof. Amit Pathak’s laboratory have developed a hydrogel system that utilizes an aldehyde-based compound to easily and reliably pre-functionalize polyacrylamide for conjugation of proteins, such as collagen and fibronectin, for cell culture applications.…
— Technology Description:
Researchers at Washington University have developed a method that allows the transduction of full-length proteins by utilizing the pTAT or pTAT-HA protein expression plasmids. A protein of choice can be fused to a HIV-TAT transduction domain under the expression system. Ba…
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