by | Oct 22, 2019 | Xu, Mai
— Background: In the US alone, 154,000 new cases of colorectal cancer (CRC) are diagnosed each year. Unfortunately, a third of those patients will die due to diagnosis at late stages – the 5-year survival rate is 11%, compared to 91% for those who are diagnosed with only localized CRC. A colonos…
by | Jul 31, 2018 | Tobin, Garry
— Technology Description: A hospital-based algorithm and associated software that is able to predict which in-patients on diabetic therapy will develop hypoglycemia. It is able to predict in real time which patients are at risk and alert MDs to start interventions to prevent possible side effects or d…
by | Jun 7, 2018 | Shaikh, Nurmohammad, Tarr, Phillip
— Primary Inventor: Phillip I. Tarr, MD
Target: GelE(mAb 8A3)
Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…
by | Mar 10, 2018 | Corbo, Joseph, Havranek, James, Mitra, Robi, Myers, Connie, Qi, Zongtai, Zhang, Chi
— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…
by | Mar 10, 2018 | Loh, Joy, Stappenbeck, Thaddeus, Thackray, Larissa, Virgin, Herbert, Wang, David, Yokoyama, Christine, Zhao, Guoyan
— Background: Mice are critical animal models for scientists investigating both basic and applied research principles. Several novel murine astroviruses have been identified in mouse facility at Washington University School of Medicine. Astroviruses are RNA viruses often associated with gastrointestin…