— Published date: 1/29/2025
Value Proposition: New chemical matter that blocks protein synthesis, eliminating infection and providing improved treatment for Toxoplasmosis.
Technology Description
Researchers at Washington University in St. Louis have identified a new chemical matter that can inh…
— Plasmids for expression of phenyl alanine tRNA synthase from Toxoplasma gondii, Plasmodium falciparum and Homo sapiens. These include wild type and various mutant forms.
— Polyclonal or monoclonal antibodies against Toxoplasma gondii proteins (ROP1, ROP5, GRA7)
Mouse anti-body ROP1 publication: Localization of a Toxoplasma gondii Rhoptry Protein by Immunoelectron Microscopy During and After Host Cell Penetration
Polyclonal rabbit antibody ROP5 publication: Virulence…
— The inventors have generated multiple gene knockout strains of T. gondii, listed below.
RH∆hx∆ku80 TIR1 (RH∆ku80∆hxgprt/pTub 5’UTR-OsTir1-3xFlag-DHFR 3’UTR-CAT):
The inventors used the CRISPR/Cas9 system for genome editing, comined with the AID degradation system to generate th…
— 2 murine hybridoma cell lines producing antibodies agains Toxoplasma gondii proteins SAG1 and MIC2
SAG1 (DG52) publication: Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii
MIC2 (6D10) publication: The Toxoplasma Adhesive Protein MIC2 Is Proteolytically Proces…
— These plasmids are for performing CRISPR/Cas9 gene editing in Cryptosporidium parvum
To generate a CRISPR/Cas9 plasmid for use in C. parvum, researchers used restriction cloning with SacI to insert the C. parvum U6 gene into a pUC19 vector to create pUC19-CpU6. We then inserted the C. parvum actin …
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Creating...
