Description: 2ftgh-ISRE-CBG99 cell line- a report line for interferon stimulation. To create these cells the inventors generated a report plasmid of interferon-stimulated response element (5xISRE)-driven luciferase, and co-transfected this vector together with pPUR plasmid into the human 2ftgh fibrosarcoma cell line.
- Patel DA, Patel AC, Nolan WC, Zhang Y, Holtzman MJ. High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery. PLoS One. 2012;7(5):e36594. doi: 10.1371/journal.pone.0036594. Epub 2012 May 4.