Chikungunya Monoclonal Antibodies

by | Feb 14, 2020 | Diamond, Michael, Fremont, Daved

— Description: Monoclonal antibodies that react with and/or neutralize Chikungunya virus

Publication:

Monoclonal Antibodies Against Zika Virus and Purified Zika E Protein

by | Dec 18, 2019 | Diamond, Michael, Fernandez, Estefania, Fremont, Daved, Nelson, Christopher, Platt, Derek, Zhao, Haiyan

— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…

Mouse and Human Anti-MR1 Hybridoma

by | Dec 5, 2019 | Cella, Marina, Colonna, Marco, Fremont, Daved, Gilfillan, Susan, Hansen, Ted, Myers, Nancy

— Target: Major Histocompatibility Complex, Class 1-Related Protein

Notes: Clone available is 26.5

Hybridoma clone 26.5 secreting mAb 26.5 to human and mouse MR1, an MHC-like molecule that restricts the activation of anti-microbial MIAT cells.

Publication: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells

Selective RANK ligand to treat osteoporosis

by | Oct 22, 2019 | Fremont, Daved, Nelson, Christopher, Teitelbaum, Steven, Warren, Julia

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Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer

Drug format – Engineered Protein

Research stage and Preliminary data – Proof of concept in vitro and in vivo

Target – Receptor A…

Target and method to treat alphavirus infections

by | Oct 22, 2019 | Basore, Katherine, Diamond, Michael, Fremont, Daved, Kim, Arthur, Nelson, Christopher, Thackray, Larissa, Zhang, Rong

— Technology Description

Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…

Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseases

by | Oct 22, 2019 | Fremont, Daved, Lu, Yun Hsuan, Lubman, Olga

— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines.

In organ transplants, chemoki…