by | May 1, 2024 | Adams, Lucas, Diamond, Michael, Fremont, Daved, Raju, Saravanan
— VLDLR-based Decoy Receptors to Prevent Alphavirus Infections
Technology Description
Researchers at Washington University in St. Louis have developed very low-density lipoprotein receptor (VLDLR) soluble decoy receptors with potent inhibitory activity in vitro and in vivo. Eastern equine encephali…
by | Feb 13, 2024 | Chheda, Milan, Diamond, Michael, Gorman, Matthew
— T-017429 Engineered Oncolytic Zika Virus Therapy for Glioblastoma
Technology Description
Researchers in the laboratories of Michael Diamond and Milan Chheda at Washington University have developed prospective treatments for glioblastoma (GBM) through the application of an engineered Zika virus (ZI…
by | Apr 29, 2021 | Adams, Lucas, Diamond, Michael, Fremont, Daved, VanBlargan, Laura
— Disease indication – SARS-CoV-2 infection (COVID-19)
Drug format – Chimeric monoclonal antibody
Drug class – Best-in-class
Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…
by | Jan 25, 2021 | Basore, Katherine, Diamond, Michael, Fremont, Daved, Kafai, Natasha, Kim, Arthur, Ma, Hongming, Thackray, Larissa
— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism
Drug format – Biologic (soluble receptor fusion protein)
Drug class – First-in-class
Mode of action – This soluble fusion protein contains domain …
by | Sep 21, 2020 | Diamond, Michael, Earnest, James
— Mayaro virus (MAYV) is an emerging mosquito-transmitted alphavirus. This is a panel of 18 neutralizing mAbs agains MAYV, 11 of which have activity that inhibited infection with EC50 values <10ng/ml.
Earnest, J. T., Basore, K., Roy, V., Bailey, A. L., Wang, D., Alter, G., ... & Diamond, M. S.…
by | Jul 20, 2020 | Diamond, Michael
— Irg1−/− mice were generated after receiving embryonic stem cells (ESCs) from the Knockout Mouse Project Repository containing an insertion cassette between exons 3 and 4. This cassette prevents transcription of downstream exons 4 and 5 and production of mature protein. Irg1−/&minu…