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Low-cost, synthetic hydrogel scaffold to promote nerve growth and regenerationRoam, Jacob ; Elbert, Donald
T-016599
— Technology Description Engineers led by Dr. Donald L. Elbert have developed a patented, self-assembling hydrogel microsphere scaffold system designed to improve tissue regeneration by creating cell migration pathways to repair large nerve gaps. This technology generates the migration pathways by c…
Therapeutic targeting of LDL in ALSRacette, Brad ; Nielsen, Susan ; Kreple, Collin ; Miller, Timothy
T-020021
— Technology Description Researchers in Brad Racette and Tim Miller’s labs at Washington University have developed a therapeutic strategy for treating ALS by using statins to lower LDL. Statins were successful at prolonging both survival and time with a normal gait. The researchers identif…
IP-10 as a blood biomarker of respiratory failureMudd, Philip
T-019671
— Technology Description Researchers in Philip Mudd’s lab at Washington University have developed a blood biomarker test that detects impending respiratory failure before existing diagnostics. High levels of the biomarker IP-10 in the blood are correlated with the subsequent development of acu…
Cell-based tumor targeting for delivering therapeutic and imaging agentsMuz, Barbara ; Azab, Abdel Kareem
T-018893
— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…
Targeted liposome drug delivery system to improve multiple myeloma treatmentFederico, Cinzia ; Azab, Abdel Kareem
T-019089
— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…
Miniature, high resolution multi-spectral imaging for label-free image guided surgery and other applicationsGarcia Hernandez, Nimrod Missael ; Gruev, Viktor
T-016872
— Technology Description Engineers in Prof. Viktor Gruev’s laboratory have developed a compact 27-band hyperspectral imaging system for high resolution, label-free, real-time imaging. This system can distinguish spectral signatures in image guided surgery (IGS) and other applications. The tech…
Controlling charge doping in 2D materialsBalgley, Jesse ; Henriksen, Erik
T-019602
— Technology Description Researchers at Washington University in St. Louis have developed a method to control charge doping in 2D materials like graphene. This method uses α-RuCl3 to create pn junctions at a smaller scale than silicon transistors. While α-RuCl3 efficiently removes el…
Rechargeable anode-free sodium metal batteryMa, Bingyuan ; Lee, Youngju ; Bai, Peng
T-019512
— Technology Description Researchers in Peng Bai’s lab at Washington University have developed an inexpensive rechargeable sodium metal battery with a 99.93% sodium retention rate. This battery uses glyme-based electrolytes with a low moisture content and a bare copper current collector to ach…
Rational drug design using Boltzmann dockingBowman, Gregory
T-016234
— Technology Description Researchers in Greg Bowman’s lab at Washington University have developed an improved method for rational drug and protein design called Boltzmann docking. This process better incorporates the dynamic structures of proteins to identify sites for binding that are not rev…
Improved MRI resolution with Diffusion Dictionary Imaging (DDI)Wang, Qing ; Wang, Yong
T-019608
— Technology Description Researchers at Washington University in St. Louis have developed MRI post-processing software capable of imaging cellular components. The software matches specific patterns with a dictionary of signals corresponding to cellular components. While the researchers have previous…
SPARTA – A Stent for Fusiform Aneurysms that Prevents EndoleaksGenin, Guy ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory ; Derdeyn, Colin ; Elbert, Donald ; Bayly, Philip ; Leuthardt, Eric
T-015969
— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…
Chimeric antigen receptor dendritic cellsDeSelm, Carl
T-019199
— Technology Description Researchers at Washington University in St. Louis have developed a genetic method to produce chimeric antigen receptor dendritic cells (CAR-DCs) for the treatment of solid tumors. The team generated a CAR that drives differentiation of cDC1s and mediates tumor-specific uptak…
Mutant PDGF-B as a VEGFR inhibitorImoukhuede, Princess
T-018996
— Technology Description Researchers in the Imoukhuede lab at Washington University have developed a library of mutant PDGF-B proteins to develop more effective VEGF pathway inhibitors. As PDGF-B also binds to VEGF receptors, a mutant form can be used to block VEGF binding and stop tumor angiogenesi…
Long non-coding RNA as cancer biomarker and drug targetSilva-Fisher, Jessica ; Fields, Ryan ; Cabanski, Christopher ; Maher, Christopher
T-018788
— Technology Description Researchers in Prof. Christopher Maher’s research program (in conjunction with collaborator Ryan Fields) discovered that RAMS11 (RNA Associated with Metastasis 11), a novel long non-coding RNA, (i) promotes metastatic disease, (ii) confers resistance to topoisomerase i…
Targeting TPL2 in RAS-mutated cancersDodhiawala, Paarth ; Lim, Kian-Huat
T-019493
— Technology Description Researchers in Kian-Huat Lim’s lab at Washington University have developed a therapeutic strategy to target TPL2 in RAS-mutated cancers, which should work synergistically with chemotherapy and radiation. As TPL2 (MAP3K8) is necessary for upstream activation of both MAP…
Low-cost, single-step vapor deposition of thin film organic perovskites for solar and memristor applicationsMyung, Yoon ; Chen, Xiao ; Banerjee, Parag
T-017124
— Technology Description Engineers in the Banerjee laboratory have developed a single-step, scalable vapor deposition process for fabricating high performance thin film perovskite materials at low temperature and atmospheric pressure. These lead-free, non-toxic films could be used as solar cell abso…
Efficient, high velocity air purification with a soft X-ray enhanced electrostatic precipitatorChadha, Tandeep ; Biswas, Pratim ; Fang, Jiaxi
T-015444
— Engineers in Prof. Pratim Biswas’ laboratory have developed an electrostatic precipitator device that removes ultrafine pollutants and inactivates pathogens from the air at high efficiency and low cost. This gas cleaning system has the potential to replace HEPA filters for air filtering applic…
An alternative approach in antimalarial drug designPavlovic Djuranovic, Slavica ; Erath, Jessey Lee ; Djuranovic, Sergej
T-018688
— Technology Description Researchers in Sergei Djuranovic’s lab at Washington University have developed polybasic peptides and polymers to block Plasmodium falciparum adhesion as a treatment for malaria. These therapeutics reduce parasite infection of human cells, making this a promising alter…
Self-capacitance Power Transfer for Efficient Wireless Charging of Small WearablesScheller, Erica ; Aono, Kenji ; Alazzawi, Yarub ; Chakrabartty, Shantanu
T-018759
— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…
Modular Pressurized Coal Combustion (MPCC) for Highly Efficient Clean Coal Energy and Gas ProductionYang, Zhiwei ; Gopan, Akshay ; Axelbaum, Richard
T-018640
— Technology Description Engineers in Prof. Richard Axelbaum’s laboratory have developed Modular Pressurized Coal Combustion (MPCC), an economical, flexible, coal-fired boiler/burner system that could produce electricity at 1.3% higher efficiency than a state-of-the-art coal-fired plant with t…
