Targeting TPL2 in RAS-mutated cancers

Tech ID: T-019493

Technology Description

Researchers in Kian-Huat Lim’s lab at Washington University have developed a therapeutic strategy to target TPL2 in RAS-mutated cancers, which should work synergistically with chemotherapy and radiation. As TPL2 (MAP3K8) is necessary for upstream activation of both MAPK and NF-κB signaling in RAS-mutated cancer cells, it provides a more appealing target for inhibitors than MEK/ERK or NF-κB alone.

In RAS-mutated cancers, inhibiting RAS-induced MAPK signaling is a common therapeutic strategy. However, tumor cells evade those therapeutics by activating NF-κB signaling instead, so targeting a protein upstream of both pathways represents a more effective strategy. The researchers have also identified several additional cancer types where mutated TPL2 is constitutively active.

Stage of Research

The researchers have identified and validated TPL2 as a therapeutic target for pancreatic cancer in vitro using a commercially-available TPL2 inhibitor. Ongoing research involves lead generation and in vivo testing.



  • Therapeutic in RAS-mediated cancers

Key Advantages

  • Central to both MAPK and NF-κB signaling pathways

Patents: Pending

Related Web Links: Lim Profile & Lab




Richards, Jennifer

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