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Isochoric Actuator
Genin, Guy ; Lee, Sanghun ; Cashin, John ; Zayed, Mohamed
T-019219

— Device used to maintain a constant volume within an isolated treatment zone while exchanging its internal volume. Current aspiration and lytic delivery thrombectomy devices do not have isolated treatment zone. Suction could result in collapse or the lysis could result in the distension of the vein wall. Device allows for tandem infusion and suction of fluids from this treatment zone while ensuring that the volume within this treatment zone remains constant.

Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E Proteins
Sukupolvi, Soila ; Shrestha, Bimmi ; Brien, James ; Diamond, Michael
T-009276

— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…

Kinase toolkit for the production of phosphorylated proteins
Sloutsky, Roman ; Stoka, Kellie ; Schaberg, Katherine ; Gale, Emily ; Naegle, Kristen
T-014736

— Background: Abnormal phosphorylation of proteins is associated with a number of human diseases including cancer, neurodegenerative disorders, and diabetes. Due to their role as phosphorlyators, kinases are popular drug targets. However, the difficulty of selectively phosphorylating a desired substra…

Improved NMR sensitivity with an integrated EPR-NMR spectrometer
Barnes, Alexander
T-014431

— Technology Description Researchers in Dr. Alexander Barnes’s lab at Washington University have developed a low-noise integrated EPR-NMR spectrometer with improved NMR sensitivity and faster acquisition times. This patented device can increase sensitivity in NMR experiments (potentially by a …

Kidney disease biomarkers for diagnosis, prognosis or clinical trials monitoring
Kim, Yeawon ; Chen, Ying
T-016375

— Technology Description Researchers in Prof. Ying “Maggie” Chen’s laboratory have identified three sensitive, urine-based biomarkers of kidney disease that could be used for non-invasive, early detection and clinical trials monitoring. In particular, these mechanistic biomarkers a…

Epigenetic drug targets to treat or prevent osteoarthritis and cartilage degradation
Shen, Jie ; McAlinden, Audrey ; O'Keefe, Regis
T-015627

— A team of researchers at Washington University in St. Louis has identified an epigenetic pathway and two therapeutic targets that could be used to prevent cartilage loss and counteract the mechanism underlying osteoarthritis. The inventors have seen promising results in a mouse model of arthritis us…

Mouse embryonic fibroblasts from IRF 3/5/7 knock out animals
Diamond, Michael
T-018546

— Mouse fibroblasts are isolated from Irf3-/-xlrf5-/-xlrf7-/-TKO mice. Researchers generated the mouse strains from an inbred C57BL/6 background. Associated Publication: IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling

anti-Powassan virus antibodies and hybridoma cell lines
VanBlargan, Laura ; Diamond, Michael
T-018559

— Murine anti-Powassan virus antibodies and hybridoma cell Publication: An mRNA Vaccine Protects Mice against Multiple Tick-Transmitted Flavivirus Infections

Plasmid pHLFcHis-Glycophorin A
Tolia, Niraj
T-018578

— Plasmid comprising the signal peptide and extracellular domain of human glycophorin A fused to antibody Fc domain and a his tag. This plasmid has been used to study malaria treatments. Publications:

Lactobacillus reuteri deltaArat
Cervantes-Barragan, Luisa ; Di Luccia, Blanda ; Caparon, Michael ; Colonna, Marco
T-018589

— Bacteria modified from the parental strain Lactobacillus reuteri 100-23 that doesn’t express the enzyme aryl aminotransferase. Culture supernatants from this bacterial strain failed to stimulate AhR reporter cells. Publication: Lactobacillus reuteri induces gut intraepithelial CD4+CD8α …

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Chandak, Rishabh ; Mehta, Darshit ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael ; Chakrabartty, Shantanu ; Altan, Ege ; Raman, Baranidharan
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

S1P1-targeted PET tracers
Yue, Xuyi ; Rosenberg, Adam ; Liu, Hui ; Tu, Zhude "Will"
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

S1PR2-targeted PET tracers
Luo, Zonghua ; Liu, Hui ; Klein, Robyn ; Tu, Zhude "Will"
T-018580

— Technology Description Researchers at Washington University in St. Louis and colleagues have developed S1PR2-targeted PET tracers. Sphingosine-1-phosphate (S1P) is an important bioactive lipid that regulates critical biological functions by acting through five specific G protein-coupled S1P recept…

Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tears
Thomopoulos, Stavros ; Yoon, Dong Hwan ; Smith, Lester ; Hoppe, Ethan ; Galatz, Leesa ; Genin, Guy
T-019211

— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…

pBAD.dCas9sth1.pAL5000 plasmid
Moon, Tae Seok
T-018499

— A plasmid constuct containing the Streptococcus thermophilus dCas9 (dCas9sth 1) gene under the control of the arabinose inducible pBAD promoter and a constitutively expressed single guide RNA (sgRNA) on the pAL5000 vector backbone. Publication: Molecular Toolkit for Gene Expression Control and Geno…

F-18 radiotracer for alpha-synuclein
Tu, Zhude "Will"
T-018513

— These materials are an alpha-synuclein binding compound (standard), and the precursor for PET radiolabeling the compound. Precursor’s code name: TZ61-23; chemical name: 2-((6-methoxypyridin-3-yl)amino)quinolin-6-ol. Standard’s code name: TZ61-44; chemical name: 6-(2-fluoroexthoxy)-N-(6-metho…

αB-crystallin (cryAB) R120G mutant knock-in mice
Andley, Usha
T-018700

— Researchers developed these knock-in mice by using homologous recombination to clone the R120G mutation into exon 3 of the αB-crystallin gene (cryab). αB-crystallin (cryAB) helps to maintain protein stability in the eye lens, which is necessary for transparency. The R120G mutation causes…

Cas9-based plasmids for engineering Synechocystis sp. PCC 6803 cyanobacteria
Zhang, Fuzhong
T-018507

— These plasmids were developed by Washington University researchers as tools for genetically engineering Synechocystis sp. PCC 6803 (S6803), a model cyanobacterium used commonly in research and biotechnology applications. Because S6803 is polyploid, genetic modification of this strain typically requi…

Methods to Treat Vasodilatory Septic Shock
Boyle, Walter
T-007528

— Background: Vasodilatory shock, a reduction in effective blood circulation, occurs when endogenous vasoconstrictor mechanisms fail as a result of an often lethal combination of severe infections. Sepsis, as one of the causes, alone affects 1 million people resulting in more than 258,000 deaths each …

Plasmids with genetic variants of CEL
Xiao, Xunjun ; Lowe, Mark
T-018959

— These plasmids encode carboxyl ester lipase (CEL) with and without genetic variants that are associated with chronic pancreatitis. To make the plasmids, the researchers used a full-length human CEL cDNA clone. The cDNA encoded for a 14-repeat VNTR, the variant present in the CEL MODY family. The Ec…