Description:

• ANKO mice: Adipose tissue-specific Nampt knockout mice
• ANKI mice: Adipose tissue-specific Nampt knockin mice (overexpressors)

Publications:

• Yoon MJ, Yoshida M, Johnson S, Takikawa A, Usui I, Tobe K, Nakagawa T, Yoshino J, Imai S. SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice. Cell Metab. 2015 May 5;21(5):706-17. doi: 10.1016/j.cmet.2015.04.002. Epub 2015 Apr 23.
• Stromsdorfer KL, Yamaguchi S, Yoon MJ, Moseley AC, Franczyk MP, Kelly SC, Qi N, Imai S, Yoshino J. NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice. Cell Rep. 2016 Aug 16;16(7):1851-60. doi: 10.1016/j.celrep.2016.07.027. Epub 2016 Aug 4.