Summaries by Inventor Yue, Xuyi

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

Alpha-synuclein ligands as specific PET imaging probes for Parkinson’s Disease and other disorders
Dhavale, Dhruva ; Kotzbauer, Paul ; Tu, Zhude "Will" ; Yue, Xuyi
T-018038

— Technology Description A team of researchers at Washington University have developed and optimized highly potent PET imaging probes which are specific for the misfolded protein that is the hallmark of Parkinson’s disease and related disorders. This family of molecules was designed based on s…

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

 

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