Summaries by Inventor Diwan, Abhinav

Transcription factor EB (TFEB) materials
Diwan, Abhinav
T-019513

— Materials that have been used to study transcription factor EB (TFEB), a lysosomal biogenesis factor:

Adenovirus: Ad-GFP-LC3, Ad-FLAG-BNIP3, Ad-mBECLIN-1, Ad-Parkin(HA), Ad-TRAF2(FLAG), Ad-TRAF2-Rm, Ad- TRAF2-deltaN. Plasmids: mCherry-GFP-LC3, DsRed-BNIP3, GFP-Parkin, GFP-LC3, DsRed-monomer-GFP fusion positive control
Diwan, Abhinav
T-017834

— Adenoviruses were generated using the Invitrogen Virapower system, which uses Clonase mediated recombination. They were generated in HEK293A cells and titered per the manufacturer’s instructions. Publications: Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death; Impaired …

CAR Macrophages for Targeted Degradation of Pathogenic Substances
DeSelm, Carl ; Diwan, Abhinav ; Lee, Jin-Moo
T-020543

— Published Date: 5/14/2025 Value proposition: Self-sustaining chimeric macrophages as a novel approach to target amyloid plaques resulting in improved efficacy and survival in patients. Technology Description Researchers from Washington University in St. Louis have engineered macrophages to expre…