by | Jan 13, 2022 | DeSelm, Carl
— Technology Description
Researchers at Washington University in St. Louis have developed a genetic method to produce chimeric antigen receptor dendritic cells (CAR-DCs) for the treatment of solid tumors. The team generated a CAR that drives differentiation of cDC1s and mediates tumor-specific uptak…
by | Nov 5, 2021 | Dodhiawala, Paarth, Lim, Kian-Huat
— Technology Description
Researchers in Kian-Huat Lim’s lab at Washington University have developed a therapeutic strategy to target TPL2 in RAS-mutated cancers, which should work synergistically with chemotherapy and radiation. As TPL2 (MAP3K8) is necessary for upstream activation of both MAP…
by | Oct 27, 2021 | Djuranovic, Sergej, Erath, Jessey Lee, Pavlovic Djuranovic, Slavica
— Technology Description
Researchers in Sergei Djuranovic’s lab at Washington University have developed polybasic peptides and polymers to block Plasmodium falciparum adhesion as a treatment for malaria. These therapeutics reduce parasite infection of human cells, making this a promising alter…
by | Sep 6, 2021 | Azab, Abdel Kareem, Azab, Feda, de la Puente Garcia, Maria del Pilar
— Background
External Beam Radiotherapy (EBR) is commonly used after surgical removal of a tumor (in e.g. a breast-conserving surgery) to control or kill malignant cells. The lack of selectivity due to irradiation of whole or partial organs from outside the body, however, is potentially damaging to t…
by | Jun 24, 2021 | Ances, Beau, Butt, Omar, DiPersio, John, Ghobadi, Armin
— Technology Description:
Researchers at Washington University in St. Louis have developed a biomarker screening assay to predict which patients receiving CAR T cell therapy will experience neurotoxicity. Patients can be screened well in advance of receiving the T cell therapy with a simple serum as…