by | Jan 29, 2021 | Mitra, Robi, Moudgil, Arnav, Wilkinson, Michael Nathaniel
— Technology Description
Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …
by | Jan 15, 2021 | Amatya, Parmeshwar, Carter, Alun, Cooper, Matthew, DiPersio, John
— Technology Description
A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…
by | Dec 11, 2020 | Luhmann, Scott
— Technology Description:
Researchers at Washington University in St. Louis have identified blood-based cytokine signatures that could be used to specifically detect, distinguish and monitor septic arthritis, synovitis and osteomyelitis. This assay could enable timely, accurate treatment to avoid joi…
by | Dec 8, 2020 | Christopher, Matthew, DiPersio, John, Ley, Timothy, Petti, Allegra, Rettig, Michael
— Technology Description
Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…
by | Nov 23, 2020 | Mitra, Robi, Moudgil, Arnav, Qi, Zongtai, Wilkinson, Michael Nathaniel
— Technology Description
Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…