Humanized rat model of Wolfram Syndrome
— A humanized rat model of Wolfram Syndrome carrying a Wfs1 gene mutation corresponding to human WFS1 gene point mutation with a stop codon at position a.a. 452.
Humanized mouse model for Wolfram Syndrome
— A mouse model of Wolfram Syndrome carrying a pathogenic variant of Wfs1 gene corresponding to human WFS1, c.1672C > T (p.R558c) missense mutation in exon 8 of WFS1.
Vectors for study of Wolfram Syndrome
— Dr. Fumihiko Urano is director of the Wolfram Syndrome International Registry at WU and has developed many research tools for studying Wolfram Syndrome.
The following constructs contain the wildtype WFS1 gene with various flags, or mutations of WFS that cause mild forms of Wolfram Syndrome (019395)…
Small molecules that inhibit Ebola viral VP35
— VP35 is involved in multiple functions crticial to viral replication in filoviruses such as Ebola and Marburg virus. Viruses with VP35 mutations are attenuated in in vivo models. 5.4 million compounds were screened for their ability to bind to VP35 at the key protein-to-protein interface. The screen…
Suicide plasmid pSL2231
— pSL2231 is a derivative of pBR322 that can be used to delete the nblA gene in Synechococcus UTEX 2973.
Publication: Synechococcus elongatus UTEX 2973, a fast growing cyanobacterial chassis for biosynthesis using light and CO2
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