by | Oct 22, 2019 | Clark, Amy, Mahadevan, Jana, Urano, Fumihiko
— Technology Description
Dr. Fumihiko Urano at Washington University in St. Louis (WUSTL) and colleagues have developed therapeutic strategies to treat Wolfram syndrome. Wolfram syndrome is a rare, life-threating, genetic disorder characterized by insulin-dependent diabetes mellitus, diabetes insipi…
by | Oct 22, 2019 | DeBosch, Brian, Higgins, Cassandra, Mayer, Allyson, Zhang, Yiming
— Background
Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease.
Technology Summary
Pharmacological or genetic activation of the Arginine…
by | Oct 22, 2019 | Doray, Balraj, Kornfeld, Stuart, Lee, Wang, Liu, Lin
— Lysosomal storage disorders result in severe, multi-system dysfunction and frequently, early death. Currently, a number of lysosomal storage disorders are treated with enzyme replacement therapy (ERT), which requires periodic infusions of the deficient enzyme. However, in a number of instances the…
by | Oct 22, 2019 | DeBosch, Brian, Higgins, Cassandra, Mayer, Allyson, Zhang, Yiming
— Background
Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease.
Technology Summary
Pharmacological or genetic activation of the Arginine…
by | Mar 10, 2018 | Ravi, V. Nathan
— Background: About 422 million people worldwide and over 29 million Americans have diabetes. The prevalence of diabetes is increasing and an important cause of blindness, amputation, kidney failure, and one of the leading causes of premature death. Diabetes is associated with significant costs. In th…