Peptides responsible for Type 1 diabetes

— Technology Description:

Researchers in the lab of Emil Unanue at Washington University have discovered a panel of peptides responsible for autoimmune activation in Type 1 diabetes and potentially capable of diagnosing T1D at an early stage. These peptide fragments of insulin are found circulating …

Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug development

— Technology Description:

Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

Device for diabetes cell replacement therapy

— Technology Description

Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…

miRNA mimics to treat metabolic disease

— Disease indication: metabolic disorders including insulin resistance and diabetic nephropathy

Drug format: chemically modified synthetic microRNA (miRNA)

Drug class: first-in-class for metabolic disease

Research stage and Preliminary data:

Target: miR-29 mimics can increase the gene expressio…

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