by | Feb 7, 2020 | Gale, Emily, Naegle, Kristen, Schaberg, Katherine, Sloutsky, Roman, Stoka, Kellie
— Background: Abnormal phosphorylation of proteins is associated with a number of human diseases including cancer, neurodegenerative disorders, and diabetes. Due to their role as phosphorlyators, kinases are popular drug targets. However, the difficulty of selectively phosphorylating a desired substra…
by | Dec 16, 2019 | Wang, Xiaowei
— Technology Description
In search of more effective cancer treatments, inventors in Dr. Xiaowei Wang’s lab at Washington University School of Medicine have developed artificial interference RNA (aiRNA). aiRNA is a patented chimeric RNAi that combines the multi-target abilities of miRNAs and t…
by | Dec 12, 2019 | Hansen, Ted, Lybarger, Lonnie, Wang, Xiaoli
— Target: Amino acids 11-34 of mouse tapasin.
Application(s): Western Blotting
Armenian hamster mAb (5D3) was produced to peptide EDAGGGGLSKKPATLLLRH GPRGP, representing residues 11–34 on mouse Tapasin (TPN) (44). TPN mAb was found to be specific for mouse TPN, as determined in a Western blot analysis of cell lysates of .221 (human TPN-positive) cells, .220 (human TPN-n…
by | Dec 1, 2019 | Hawkins, William, Hotchkiss, Richard, Spitzer, Dirk
— WUSTL Technology 007646
Technology Description
Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…
by | Oct 22, 2019 | Finkbeiner, Stacy, Virgin, Herbert, Wang, David, Zhao, Guoyan
— Technology Description
A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics.
The virus (…