Office of Technology Management/Tech Transfer

WASHU INNOVATION CATALOG

Transgenic mouse lines with markers of muscle development

by | Nov 20, 2019 | Sanes, Joshua

— Myl-CFP Mice

The coding sequence for the enhanced CFP was inserted downstream of ~5kb of putative regulatory sequences from the mouse myosin Type I heavy chain gene. Transgenic mice were generated by pronuclear injection using standard methods.

JAX Stock No. 06922

MyIIA-RFP Mice

A ~100kb genomic…

Floxed ChAT mouse strain

by | Nov 20, 2019 | Burgess, Robert, Sanes, Joshua

— This mouse strain has loxP sites flanking exons 3 and 4 of the ChAT gene. There is a Neo gene in the intron between exons 4 and 5. Mating these mice to A-Cre mice generates a null allele in subsequent generations, in which no ChAT protein or activity is detectable. The mice are maintained in the C57…

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