Office of Technology Management/Tech Transfer

WASHU INNOVATION CATALOG

B-122 and Alf-161 – Hamster IgG Monoclonal Antibodies against Mouse/Rat IL-1 Beta and Mouse IL-1 Alpha

by | Nov 6, 2019 | Chaplin, David, Schreiber, Robert, Unanue, Emil

— Target: Mouse/rat interleukin-1 beta and mouse interleukin-1 alpha. Located on macrophages, dendritic cells, T and B cells.

Notes: Clone name is B-122 and Alf-161

Information on antibodies against IL-1 beta:

The role of murine IL-1 beta in vitro and in vivo has not been defined. We describe here the production of neutralizing and immunoprecipitating mAb and polyclonal antibodies specific for murine IL-1 beta and their application to a characterization of the…

IL-1 beta deficient mice

by | Oct 30, 2019 | Chaplin, David, Ferguson, Thomas

— Mouse strain deficient in IL-1 beta

Inventors created the IL-1 beta deficient mouse strain by targeting the IL-1 beta gene in embryonic stem cells. These mice develop and grow normally. Endotoxin-stimulated peritoneal macrophages from IL-1beta- deficient mice showed normal synthesis and cellular release of IL- 1alpha after treatment w…
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