Search returned 682 results
Antiviral therapy targeting viruses within parasitic protozoansKuhlmann, Frederick ; Beverley, Stephen
T-016969
— Background: Parasitic infections remain global health threats and often lead to high death rates in endemic countries. Found in 98 countries, the Leishmania parasite is particularly dangerous and accounts for an estimated 2 million cases and 50,000 deaths per year across the world. However, Leishman…
Drugs to supplement microglial metabolism during treatment of Alzheimer’s diseaseUlland, Tyler ; Colonna, Marco
T-017401
— Background: Alzheimer’s disease (AD) is the 6th leading cause of death in the United States, and yet causation of the disease is poorly understood and targets for therapeutic intervention are still being identified. Recently, mutations in the immune receptor TREM2 have been found to be strongl…
Lysosomal Enzyme GlcNAc-1-phosphotransferase with Enhanced Ability to Phosphorylate Lysosomal EnzymesLee, Wang ; Liu, Lin ; Doray, Balraj ; Kornfeld, Stuart
T-016569
— Lysosomal storage disorders result in severe, multi-system dysfunction and frequently, early death. Currently, a number of lysosomal storage disorders are treated with enzyme replacement therapy (ERT), which requires periodic infusions of the deficient enzyme. However, in a number of instances the…
Styryl Heteroaromatic Ring Containing Analogues for Alpha-SynucleinLi, Junfeng ; Yue, Xuyi ; Kotzbauer, Paul ; Tu, Zhude "Will"
T-014558
— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…
Tetrahedron Beam Computed Tomography with Multi-pixel X-ray SourceZhang, Tiezhi
T-015342
— About 70 million computed tomography (CT) scans are performed in the United State alone each year. Traditional helical scanners use a single point x-ray source that rotates around the patient, acquiring images in sequential slices, which results in high quality images. But these helical scanners a…
A Truly Tumor-Specific Epitope Carried by BG-A Antigen for Cancer Diagnosis and TreatmentXu, Mai
T-016998
— Background: In the US alone, 154,000 new cases of colorectal cancer (CRC) are diagnosed each year. Unfortunately, a third of those patients will die due to diagnosis at late stages – the 5-year survival rate is 11%, compared to 91% for those who are diagnosed with only localized CRC. A colonos…
High Throughput Acoustic Particle SeparationBerezin, Mikhail ; Binkley, Michael ; Meacham, John
T-017364
— Technology Description: Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices. Applications: 1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…
Hamster Hybridoma producing Monoclonal Antibody against Mouse CXCL9Sheehan, Kathleen ; Schreiber, Robert
T-005944
— Target: Inflammatory chemokine CXCL9, monokine induced by IFN-gamma. Secreted mainly by macrophages. Notes: Clone MIG-2F5-5. Use in ELISA, neutralizing and binding assays.
Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD158iColonna, Marco
T-005376
— Target: A member of the killer immunoglobulin-like receptor (KIR) family expressed on natural killer cells. Notes: Clone JJC116
Murine Hybridoma producing IgG1 Monoclonal Antibody to Human NKp30Colonna, Marco
T-005378
— Target: NKp30 (aka CD337) is an natural killer cell receptor. Notes: Clone name is AF29-4D12.
Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD226 (DNAM-1)Colonna, Marco
T-005408
— Target: CD226 is a glycoprotein expressed on natural killer cells, platlets, monocytes and a subset of T cells. Notes: Clone name is 11A8, used for flow cytometry.
Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD155Colonna, Marco
T-005410
— Target: Cluster of Differentiation 155 protein, a.k.a. Poliovirus Receptor. Notes: Clone name is SKII.4.
Murine Hybridoma producing IgG1 Monoclonal Antibody to Human SIRP Alpha + BetaColonna, Marco
T-005413
— Target: Cluster of Differentiation 172g protein, a.k.a. Signal Regulatory Protein Alpha and Beta. Notes: Clone name is 148.
Murine Hybridoma producing IgG2a Monoclonal Antibody to Mouse Rae1 DeltaColonna, Marco
T-005805
— Target: Retinoic Acid Early 1 Delta protein. Notes: Clone Charlotte O1.23.
Murine Hybridoma producing IgG1 Monoclonal Antibody to Human B7-H3Colonna, Marco
T-007604
— Target: Cluster of Differentiation, a.k.a. Neural Cell Adhesion Molecule. Notes: Clone name is DCN.70.
Rat Hybridoma producing IgG2b mAB to Mouse Natural IPC-Specific AntigenColonna, Marco
T-005806
— Target: Natural Interferon-Producing Cell-Specific Antigen Notes: Clone available is 440c
Venezuelan Equine Encephalitis Virus (VEEV) AntibodiesDiamond, Michael
T-015386
— Primary Inventor: Michael S. Diamond, MD Target: Venezuelan Equine Encephalitis Virus
Anti-prM Monoclonal Antibody against all four Dengue Virus SerotypesDiamond, Michael
T-015814
— Target: Dengue Virus Notes: PrM-12 and -22
Recombinant Chikungunya Virus Soluble E2 ProteinDiamond, Michael ; Pal, Pankaj ; Fremont, Daved ; Barrow, Melissa
T-014734 Knockout Mouse lacking Expression of the Batf3 Gene
Murphy, Theresa ; Schreiber, Robert ; Unanue, Emil ; Diamond, Michael ; Murphy, Kenneth
T-009136
— Notes: Batf3-/- knockout mouse with a 129SvEv background.
