— Target: Retinoic Acid Early 1 Delta protein. Notes: Clone Charlotte O1.23.

— Target: Cluster of Differentiation, a.k.a. Neural Cell Adhesion Molecule. Notes: Clone name is DCN.70.

— Target: Natural Interferon-Producing Cell-Specific Antigen Notes: Clone available is 440c

— Primary Inventor: Michael S. Diamond, MD Target: Venezuelan Equine Encephalitis Virus

— Target: Dengue Virus Notes: PrM-12 and -22

— Notes: Batf3-/- knockout mouse with a 129SvEv background.

— Notes: Mouse model with the mutation for NPC knocked in.

— Notes: Btla-/- knockout mouse with a 129S/SvEv background. B6.129.Btla tm1kmm/J Mouse.

— Background 8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…

— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

— Technology Description: The mannose receptor is uniquely found on macrophages and not on monocytes, making the mannose receptor a target for macrophage activation. Researchers at Washington University have developed polypeptide backbones to target the mannose receptor on macrophages. This technology…

— Background Gaucher and Krabbe disease are two types of lipid (fat) storage diseases that can result in progressive damage to the nervous system and other organ systems. Together, these diseases affect about 450,000 people worldwide. In both of these diseases, there is an undesirable accumulation of…

— Background: Anion exchange membranes (AEMs) are used as separators in redox flow batteries, water electrolyzers, water desalination systems, fuel cells, and other electrochemical devices. Current AEMs suffer from issues with cost, poor stability and low perm selectivity. For example, current redox flow batteries are not economical or suffer from capacity loss upon cycling due to cross species contamination while using less expensive decoupled chemistries.An advanced, tunable AEM has been developed with dramatically reduced cost and improved performance relative to industry leading AEMs. High ionic conductivity, chemical stability and enhanced mechanical performance have been shown. The technology includes tunable membrane compositions, mechanical re…

— Technology Description: Researchers at Washington University have developed a method that allows the transduction of full-length proteins by utilizing the pTAT or pTAT-HA protein expression plasmids. A protein of choice can be fused to a HIV-TAT transduction domain under the expression system. Ba…

— Technology Summary: Obesity rates worldwide are increasing at an astounding rate. While diet, lifestyle, and physical activity have traditionally been identified as the main causative factors, researchers at Washington University are the first to implicate gut bacteria (microbiome) as a new drivin…

— Background Quantitation of relative or absolute amounts of proteins by mass spectrometry can be prone to large errors. The use of MS/MS ion intensities and stable isotope labeling, a method called isotope labeling tandem mass spectrometry (SILT), decreases the effects of contamination from unrelate…

— Background Targeted delivery of cytotoxic therapeutics is crucial to prevent adverse side effects of chemotherapy and to increase drug concentrations at the tumor site. These prerequisites also apply to the treatment of infections caused by multiple drug resistant bacteria. To address this unmet n…