— Mouse strain deficient in IL-1 betaInventors created the IL-1 beta deficient mouse strain by targeting the IL-1 beta gene in embryonic stem cells. These mice develop and grow normally. Endotoxin-stimulated peritoneal macrophages from IL-1beta- deficient mice showed normal synthesis and cellular release of IL- 1alpha after treatment w…

— Technology Description Engineers in Prof. Roger Chamberlain’s laboratory have developed a low-cost multiplexing technology for high-speed optical communications in data centers and other short-haul applications. This visible light communication (VLC) system is designed to create distinct par…

— Background: Its unique imaging characteristics and favorable half-life and decay properties make radioisotope copper-64 (Cu-64) most desirable for PET imaging. To meet the increasing demand, an efficient high yielding Cu-64 manufacturing process is essential. To address this unmet need, scientists f…

— Researchers in Prof. Fuzhong Zhang’s laboratory have developed a simple, scalable, broadly-applicable system to enhance fermentation efficiency for biosynthetic production of biofuels, pharmaceuticals, materials and other useful chemicals. Currently, biosynthetic pathways have enabled renewabl…

— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…

— Lihong Wang, Professor at Washington University in St. Louis, is a pioneer in the field of Photoacoustic (PA) Imaging. His innovations have enabled non-invasive imaging of living organisms at scales ranging from subcellular to whole-body at depths and resolutions that are simply impossible with any …

— This novel immunohistochemical marker would be a valuable diagnostic aid to the practicing surgical pathologist who is confronted with this particular diagnostic challenge. Companies may license this antibody for clinical testing, or cases may be referred to Washington University for subspecialty c…

— Rabbit polyclonal antibodies were generated using two distinct 20-mer synthetic peptides corresponding to the unique C-terminal extension of HuCKI 3 using standard protocols. Final purification used the corresponding peptide immunogen affinity column. Possible uses: histological detection in tumors …

— This is a monoclonal antibody specific for NT-Pro BNP and can be used singly in a competitive immunoassay to measure the amount of this analyte in blood samples for the purpose of diagnosis or monitoring of congestive heart failure. In addition, it could be used in a sandwich immunoassay with a mono…

— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…

— The invention is a novel photoacoustic imaging technique, termed reversibly switchable photoacoustic tomography (RS-PAT). It exhibits a large penetration depth, a high detection sensitivity, and a spatial super-resolution. The most important feature of this technique is that it significantly incre…

— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…

— Zuum is a health-risk assessment software that serves as a prognostic for various types of cancer.

— Quit Helpers is an interactive web-based tool to recommend pharmacotherapy to smokers based on medical and personal factors. Although general information about cessation aids is abundant, Quit Helpers automates the process of identifying a specific cessation aid or combination of aids for individua…

— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…

— The monoclonal antibodies developed are agaonistic monoclonal antibodies. These antibodies can help in enhancing the immune system by activating dendritic cell subsets. Furthermore, these antibodies are unique, as they can activate Dendritic cells without the need for cross-linking the receptor.

— To order a NEO Assessment, Click Here. If the link does not work, copy and paste https://commerce.cashnet.com/NEO into your search bar. Summary: Eating is an important part of daily life; it ensures nutrition for growth and is an important activity of daily living with strong social implications. …

— Dr. Hiroko Yano and Dr. Albert Kim, and their research teams at the Washington University School of Medicine in St. Louis developed and extensively evaluated a novel therapeutic approach using DNMT inhibitors to treat Huntington’s Disease (HD) and other neurodegenerative disorders. Currently D…

— Background: Worldwide, there are over 10 million new cases of tuberculosis (TB) annually, resulting in 1.8 million deaths. This makes Mycobacterium tuberculosis (Mtb), the bacterium causing TB, the world’s leading infectious disease killer. Even for drug susceptible TB, the treatment courses a…

— Background: Natural Killer (NK) and T cells are the primary immune cells being explored for cancer immuntherapy. NK cells are relatively short-lived, making the therapy less susceptible to some of the side effects currently associated with using T cells for immunotherapy. Unlike T cells, NK cells ar…