— C57BL/6 ES cells were targeted with a vector (European Conditional Mouse Mutagenesis Program) carrying loxP sites flanking exon 3 of mouse Cept1. A karyotypically normal clone (of 10 correctly targeted) was injected into B6(Cg)-Tyrc-2J/J blastocysts and chimeric mice were bred with B6(Cg)-Tyrc2J/J f…

— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…

— Technology Description: Researchers at Washington University in St. Louis have identified blood-based cytokine signatures that could be used to specifically detect, distinguish and monitor septic arthritis, synovitis and osteomyelitis. This assay could enable timely, accurate treatment to avoid joi…

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

— Technology Description Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

— Technology Description This technology is a patented method aimed at increasing the success rate of atrial fibrillation (AF) treatment by designing customized, patient-specific cardiac ablation lesion sets. AF, the most common sustained cardiac arrhythmia, has traditionally been treated with a ma…

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

— Technology Description Researchers in Prof. Netanel Raviv’s laboratory have developed a provable error correcting code (ECC) system that could guarantee deep neural networks (DNN) are resilient to noise for robust, secure and private neural computation. This technology could be deployed in n…

— Technology Description Researchers in Prof. Netanel Raviv’s laboratory have developed a provable error correcting code (ECC) system that could guarantee deep neural networks (DNN) are resilient to noise for robust, secure and private neural computation. This technology could be deployed in n…

— Brief Description A team of engineers at Washington University in St. Louis have developed a synthetic biology platform for low-cost, sustainable production of high-performance composite materials. This technology uses a split intein assembly system to synthesize high molecular weight polymers (e.…

— Technology Description Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…

— Technology Description Researchers at Washington University developed a prognostic assay for multiple myeloma that detects the full range of common multiple myeloma mutations using a single capture-based sequencing platform. This technology utilizes probes designed to analyze 465 genes associated …

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

— Researchers in Prof. Sheng-Kwei (Victor) Song’s laboratory have developed diffusion histology imaging (“DHI”), a tool to provide a non-invasive diagnosis for accurately grading tumors and guiding treatment decisions. This “virtual histopathology” technology classifies mic…

— This panel of antibodies against the SARS-CoV-2 spike protein has potential applications for research or diagnostics (e.g., sandwich ELISA to quantify or detect spikes in biological fluid).

— These are six monoclonal antibodies specific to SARS-CoV-2 Nucleocapsid protein that could potentially be used for COVID-19 diagnostics.