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IP-10 as a blood biomarker of respiratory failureMudd, Philip
T-019671
— Technology Description Researchers in Philip Mudd’s lab at Washington University have developed a blood biomarker test that detects impending respiratory failure before existing diagnostics. High levels of the biomarker IP-10 in the blood are correlated with the subsequent development of acu…
Low-cost, synthetic hydrogel scaffold to promote nerve growth and regenerationRoam, Jacob ; Elbert, Donald
T-016599
— Technology Description Engineers led by Dr. Donald L. Elbert have developed a patented, self-assembling hydrogel microsphere scaffold system designed to improve tissue regeneration by creating cell migration pathways to repair large nerve gaps. This technology generates the migration pathways by c…
Targeted liposome drug delivery system to improve multiple myeloma treatmentFederico, Cinzia ; Azab, Abdel Kareem
T-019089
— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…
Cell-based tumor targeting for delivering therapeutic and imaging agentsMuz, Barbara ; Azab, Abdel Kareem
T-018893
— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…
Cell-based tumor targeting for delivering therapeutic and imaging agentsMuz, Barbara ; Azab, Abdel Kareem
T-018893
— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…
Targeted liposome drug delivery system to improve multiple myeloma treatmentFederico, Cinzia ; Azab, Abdel Kareem
T-019089
— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…
Miniature, high resolution multi-spectral imaging for label-free image guided surgery and other applicationsGarcia Hernandez, Nimrod Missael ; Gruev, Viktor
T-016872
— Technology Description Engineers in Prof. Viktor Gruev’s laboratory have developed a compact 27-band hyperspectral imaging system for high resolution, label-free, real-time imaging. This system can distinguish spectral signatures in image guided surgery (IGS) and other applications. The tech…
Miniature, high resolution multi-spectral imaging for label-free image guided surgery and other applicationsGarcia Hernandez, Nimrod Missael ; Gruev, Viktor
T-016872
— Technology Description Engineers in Prof. Viktor Gruev’s laboratory have developed a compact 27-band hyperspectral imaging system for high resolution, label-free, real-time imaging. This system can distinguish spectral signatures in image guided surgery (IGS) and other applications. The tech…
Controlling charge doping in 2D materialsBalgley, Jesse ; Henriksen, Erik
T-019602
— Technology Description Researchers at Washington University in St. Louis have developed a method to control charge doping in 2D materials like graphene. This method uses α-RuCl3 to create pn junctions at a smaller scale than silicon transistors. While α-RuCl3 efficiently removes el…
Controlling charge doping in 2D materialsBalgley, Jesse ; Henriksen, Erik
T-019602
— Technology Description Researchers at Washington University in St. Louis have developed a method to control charge doping in 2D materials like graphene. This method uses α-RuCl3 to create pn junctions at a smaller scale than silicon transistors. While α-RuCl3 efficiently removes el…
Subtyping of schizophrenia based on genome and pathologySvrakic, Dragan ; Cloninger, C. Robert ; Zwir, Jorge "Igor"
T-015118
— Technology Description Researchers in Igor Zwir’s lab at Washington University have developed a diagnostic system to categorize patients with schizophrenia into 8 sub-groups. The system recommends a sub-group based on both genetic and psychopathology data and provides clinicians with a knowl…
Rechargeable anode-free sodium metal batteryMa, Bingyuan ; Lee, Youngju ; Bai, Peng
T-019512
— Technology Description Researchers in Peng Bai’s lab at Washington University have developed an inexpensive rechargeable sodium metal battery with a 99.93% sodium retention rate. This battery uses glyme-based electrolytes with a low moisture content and a bare copper current collector to ach…
A companion diagnostic to SARM1 inhibitors for neurodegenerative diseasesMilbrandt, Jeffrey ; Mao, Xianrong ; DiAntonio, Aaron ; Bloom, Adam
T-019378
— Technology Description Researchers at Washington University, led by Jeffrey Milbrandt, have developed a companion diagnostic for SARM1 inhibitors that detects pathogenic variants of the SARM1 gene. Patients with one of several identified variants of SARM1 would respond well to SARM1 inhibitor thera…
Rational drug design using Boltzmann dockingBowman, Gregory
T-016234
— Technology Description Researchers in Greg Bowman’s lab at Washington University have developed an improved method for rational drug and protein design called Boltzmann docking. This process better incorporates the dynamic structures of proteins to identify sites for binding that are not rev…
Improved MRI resolution with Diffusion Dictionary Imaging (DDI)Wang, Qing ; Wang, Yong
T-019608
— Technology Description Researchers at Washington University in St. Louis have developed MRI post-processing software capable of imaging cellular components. The software matches specific patterns with a dictionary of signals corresponding to cellular components. While the researchers have previous…
SPARTA – A Stent for Fusiform Aneurysms that Prevents EndoleaksSuh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; McCoy, Kathleen ; Bayly, Philip ; Leuthardt, Eric
T-015969
— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…
Chimeric antigen receptor dendritic cellsDeSelm, Carl
T-019199
— Technology Description Researchers at Washington University in St. Louis have developed a genetic method to produce chimeric antigen receptor dendritic cells (CAR-DCs) for the treatment of solid tumors. The team generated a CAR that drives differentiation of cDC1s and mediates tumor-specific uptak…
Mutant PDGF-B as a VEGFR inhibitorImoukhuede, Princess
T-018996
— Technology Description Researchers in the Imoukhuede lab at Washington University have developed a library of mutant PDGF-B proteins to develop more effective VEGF pathway inhibitors. As PDGF-B also binds to VEGF receptors, a mutant form can be used to block VEGF binding and stop tumor angiogenesi…
Molecular imaging of COVID binding receptorZhang, Hanwen ; Abou, Diane ; Thorek, Daniel
T-019485
— Technology Description A team of researchers led by Professor Daniel Thorek at Washington University have developed a peptide specific to human ACE2, the receptor for SARS-CoV-2, that can be used for imaging or therapeutic delivery. The peptide can be easily chelated for PET imaging, allowing for …
Long non-coding RNA as cancer biomarker and drug targetSilva-Fisher, Jessica ; Fields, Ryan ; Cabanski, Christopher ; Maher, Christopher
T-018788
— Technology Description Researchers in Prof. Christopher Maher’s research program (in conjunction with collaborator Ryan Fields) discovered that RAMS11 (RNA Associated with Metastasis 11), a novel long non-coding RNA, (i) promotes metastatic disease, (ii) confers resistance to topoisomerase i…