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Myocardial perfusion SPECT optimizationSiegel, Barry ; Yu, Zitong ; Rahman, Md Ashequr ; Jha, Abhinav Kumar
T-020357
— T-020357, T-020358, T-020744 Myocardial perfusion SPECT optimization Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised methods to reliably improve and personalize myocardial perfusion SPECT imaging. The inventions include the following capa…
Small Molecule Agonists of EphA Receptors to Ameliorate DiabetesDolle, Roland "Ron" ; Asadi Jomnani, Farzad ; Piston, David
T-020153
— T-020153 – Small Molecule Agonists of EphA Receptors to Ameliorate Diabetes Technology Description Blood glucose levels (left), post-treatment plasma glucagon (center) in WCDD301 treated NOD (non-obese diabetic) mice with moderate hyperglycemia. Blood glucose levels (right) in Streptozotocin-ind…
Systems and Methods for Detection and Quantification of Axial SpondyloarthritisYokoyama, Wayne ; Paley, Michael
T-020486
— T-020486 – Systems and Methods for Detection and Quantification of Axial Spondyloarthritis Technology Description Researchers at Washington University in St. Louis, led by Dr. Michael Paley, have developed an assay to diagnose axial spondyloarthritis (axSpA) in HLA-B*27-positive patients.…
Robust Suite of Technologies Offers Significant Enhancements for Whispering Gallery Mode (WGM) Microresonator Sensors and Laser SystemsOzdemir, Sahin ; Yang, Lan ; He, Lina ; Chen, Da-Ren ; Zhu, Jiangang
T-009642
— WGM microresonators are an immature technology with room for improvement Microresonators are optical devices that are an important component of microlasers used in optoelectronics, data communications, and sensing. Most microresonators are WGM type, which confine light to a very small volume for si…
Development of CD163 targeting agent for imaging and therapyZhang, Xiuli ; Heo, Gyu Seong ; Liu, Yongjian
T-020196
— T-020196 CD163 Targeting Agent for Imaging and Therapy Technology Description Researchers in Yongjian Liu’s laboratory at Washington University have synthesized a new peptide-based CD163 radiotracer. CD163 is a well-known biomarker specific to macrophages implicated in multiple diseases, but…
Tissue-penetrating PET radiotracer for non-invasive detection of ROS and inflammationSivapackiam, Jothilingam ; Sharma, Vijay
T-019479
— T-019479 Tissue-penetrating PET radiotracer for non-invasive detection of ROS and inflammation. Technology Description 18F-fluorodeoxyglucose (18F-FDG) has long been used for the diagnosis of neoplasms, and recently Alzheimer’s disease. However, 18F-FDG signals are often not correlated with…
PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen SpeciesSivapackiam, Jothilingam ; Satham, Lakshminarayana ; Sharma, Vijay
T-020300
— T-020300 PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen Species Technology Description Reactive Oxygen Species (ROS) is known to contribute to the pathogenesis of neuropathological conditions such as Alzheimer’s disease and cancer. However, there …
Comprehensive Test Suite for Radiotherapy Machines Fully Automates Acceptance, Commissioning, and Daily Quality Assurance for Increased ProfitabilityMahon, Rebecca "Nicky" ; Raman, Caleb ; Reynoso, Francisco ; Sun, Baozhou ; Wu, Yu ; Knutson, Nels ; Hao, Yao ; Schmidt, Matthew
T-019746
— Quality assurance is critical in the setup and operation of linear accelerators (LINACs) and requires significant time and expense Before they can be put into use, new LINAC radiotherapy machines and their integrated treatment planning systems (TPSs) must go through a labor-intensive acceptance and…
Uropathogen VaccinesTimm, Morgan ; Feldman, Mario ; Pinkner, Jerome ; Tamadonfar, Kevin ; Ellebedy, Ali ; Dodson, Karen ; Hultgren, Scott
T-020120
— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…
Super-Resolution Dental Tetrahedron Beam Computed Tomography (TBCT) System Improves Image Quality Without Sacrificing Speed for Expanded Clinical ApplicationsZhou, Shuang ; Tan, Yuewen ; Chen, Qinghao ; Zhang, Tiezhi
T-019620
— Current cone beam computed tomography (CBCT) systems lack concurrent high-resolution imaging and speed With current digital CBCT imaging technology, x-ray tube power limitations mean high-resolution images can only be achieved by reducing imaging speeds. In dental applications, CBCT suffers from im…
MRI neural network segmentation in atherosclerosisLi, Ran ; Zheng, Jie ; Jha, Abhinav Kumar ; Woodard, Pamela
T-020254
— Technology Description Researchers at Washington University in St. Louis have developed a two-stage neural network model, with CNN and BNN architecture, to segment carotid atherosclerotic plaque components based on multi-weighted MR images and measure the uncertainty of the segmentation output. Th…
Optimized Non-Coplanar Radiation Delivery for Simpler, Faster, and Safer TreatmentsMutic, Sasa ; Zhang, Tiezhi
T-016307
— Existing LINACs inefficiently deliver non-coplanar beams The goal of radiation treatment is to precisely deliver a prescribed radiation dose to the targeted tissue, while avoiding dosing the surrounding normal tissues and organs. These treatments require radiation beams to be delivered from multipl…
Passive and Compact Liquid Metal Heat SwitchWeisensee, Patricia
T-019180
— Technology Description Researchers in Patricia Weisensee’s lab at Washington University have developed a compact liquid metal heat switch with a passive mechanism to control the thermal management system of spacecraft. Unlike other switch mechanisms, the liquid metal version produces high co…
Trackable pedicle screwsLowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob ; Genin, Guy ; Hacker, Carl ; Brunner, Peter ; Leuthardt, Eric
T-019941
— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…
Arteriovenous graft designed to prevent thrombosis and graft failureWilliams, Dillon ; Genin, Guy ; Zayed, Mohamed
T-018994
— Technology Description Prof. Mohamed Zayed and colleagues have developed an arteriovenous graft cuff with features designed to normalize the blood shear rate and decrease risk of thrombosis at the venous end anastomosis. This device could reduce the failure rate of these grafts, thereby improving …
Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogensLee, Jin Vivian ; Iqbal, Zahid ; Zayed, Mohamed
T-019443
— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…
High-throughput blood biomarker test for peripheral atherosclerosisSemenkovich, Clay ; Zayed, Mohamed
T-017421
— Technology Description Researchers from Mohamed Zayed’s lab at Washington University have developed a blood biomarker test for atherosclerosis more accurate than LDL. Circulating levels of Fatty Acid Synthase (cFAS) in the serum correlate to a high degree to severity of peripheral atheroscle…
Blockchain-based algorithms for secure, collaborative risk assessment and decision makingSalman, Tara ; Jain, Raj
T-018710
— Technology Description Researchers in Prof. Raj Jain’s laboratory have developed a new type of algorithm that extends the security of decentralized blockchains from consensus validation to efficient group decision making. This technology, called “probabilistic blockchains”, provi…
Deep Learning-Assisted Image Reconstruction for Tomographic ImagingMatthews, Thomas ; Kelly, Brendan ; Anastasio, Mark
T-017311
— Background Image reconstruction for any modern imaging technique is an optimization problem. Most image reconstructions methods are iterative in nature and produce sequential intermediate images that are compared to the raw acquisition data and subsequently updated to maximize the likelihood that t…
Range finder to improve X-ray image collectionClayton, William ; Don, Steven
T-014196
— Technology Description Researchers at Washington University in St. Louis have developed a device that automatically measures and displays body thickness to optimize X-ray image collection. This device will improve X-ray image quality and reduce the radiation exposure to patients. The device es…
