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Calcium Carbonate nanoparticles for normalizing tumor microenvironmentAchilefu, Samuel
T-018647
— Description: Calcium Carbonate nanoparticles for normalizing tumor microenvironment Publication: Som A, Raliya R, Tian L, Akers W, Ippolito JE, Singamaneni S, Biswas P, Achilefu S. Monodispersed calcium carbonate nanoparticles modulate local pH and inhibit tumor growth in vivo. Nanoscale. 2016 Jul …
pDD82, pDD112 and pDD120 plasmidsMoon, Tae Seok
T-018659
— Description: Plasmids- Publication: DeLorenzo DM, Rottinghaus AG, Henson WR, Moon TS. Molecular Toolkit for Gene Expression Control and Genome Modification in Rhodococcus opacus PD630. ACS Synth Biol. 2018 Feb 16;7(2):727-738. doi: 10.1021/acssynbio.7b00416. Epub 2018 Feb 5.
Dnmt3b transgenic miceO'Keefe, Regis
T-018661
— Description: Dnmt3b transgenic mouse contains a full-length Flag-tagged murine Dnmt3b cDNA which is under the control of a rtTA promoter. The Dnmt3b transgenic mouse will provide both cell specific and temporal regulation for Dnmt3b over-expression upon recombination with addition of doxycycline (D…
Irg1 point mutant miceNair, Sharmila ; Diamond, Michael
T-018684
— Description: CRISPR-Cas9 gene edited mice with point mutation in Irg1 (ACOD1). Note: Please contact for additional information.
Light Sheet Microscopy with Objective-Coupled Selective Plane IlluminationHolekamp, Terrence ; Holy, Timothy
T-005916
— Technology Description Researchers in Prof. Timothy Holy’s laboratory at Washington University in St. Louis are among the independent inventors of light sheet fluorescence microscopy and the first to use it for large-scale calcium imaging. This patented technology, OC-SPIM (objective-coupled…
Scalable synthesis of stable, highly conductive, solution-processable PEDOT particles for organic electronicsLu, Yang ; D'Arcy, Julio M.
T-019278
— Technology Description Researchers in Prof. Julio D’arcy’s laboratory have developed aerosol vapor polymerization (AVP), a scalable continuous batch-processing platform to produce bulk quantities of stable submicron conductive particles for organic electronics. Unlike traditional PEDOT…
Isochoric ActuatorGenin, Guy ; Lee, Sanghun ; Cashin, John ; Zayed, Mohamed
T-019219
— Device used to maintain a constant volume within an isolated treatment zone while exchanging its internal volume. Current aspiration and lytic delivery thrombectomy devices do not have isolated treatment zone. Suction could result in collapse or the lysis could result in the distension of the vein wall. Device allows for tandem infusion and suction of fluids from this treatment zone while ensuring that the volume within this treatment zone remains constant.
Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E ProteinsShrestha, Bimmi ; Sukupolvi, Soila ; Brien, James ; Diamond, Michael
T-009276
— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…
Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E ProteinsSukupolvi, Soila ; Shrestha, Bimmi ; Brien, James ; Diamond, Michael
— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…
Kinase toolkit for the production of phosphorylated proteinsSloutsky, Roman ; Stoka, Kellie ; Schaberg, Katherine ; Gale, Emily ; Naegle, Kristen
T-014736
— Background: Abnormal phosphorylation of proteins is associated with a number of human diseases including cancer, neurodegenerative disorders, and diabetes. Due to their role as phosphorlyators, kinases are popular drug targets. However, the difficulty of selectively phosphorylating a desired substra…
Improved NMR sensitivity with an integrated EPR-NMR spectrometerBarnes, Alexander
T-014431
— Technology Description Researchers in Dr. Alexander Barnes’s lab at Washington University have developed a low-noise integrated EPR-NMR spectrometer with improved NMR sensitivity and faster acquisition times. This patented device can increase sensitivity in NMR experiments (potentially by a …
Kidney disease biomarkers for diagnosis, prognosis or clinical trials monitoringKim, Yeawon ; Chen, Ying
T-016375
— Technology Description Researchers in Prof. Ying “Maggie” Chen’s laboratory have identified three sensitive, urine-based biomarkers of kidney disease that could be used for non-invasive, early detection and clinical trials monitoring. In particular, these mechanistic biomarkers a…
Kidney disease biomarkers for diagnosis, prognosis or clinical trials monitoringKim, Yeawon ; Chen, Ying
T-016375
— Technology Description Researchers in Prof. Ying “Maggie” Chen’s laboratory have identified three sensitive, urine-based biomarkers of kidney disease that could be used for non-invasive, early detection and clinical trials monitoring. In particular, these mechanistic biomarkers a…
Epigenetic drug targets to treat or prevent osteoarthritis and cartilage degradationShen, Jie ; McAlinden, Audrey ; O'Keefe, Regis
T-015627
— A team of researchers at Washington University in St. Louis has identified an epigenetic pathway and two therapeutic targets that could be used to prevent cartilage loss and counteract the mechanism underlying osteoarthritis. The inventors have seen promising results in a mouse model of arthritis us…
Mouse embryonic fibroblasts from IRF 3/5/7 knock out animalsDiamond, Michael
T-018546
— Mouse fibroblasts are isolated from Irf3-/-xlrf5-/-xlrf7-/-TKO mice. Researchers generated the mouse strains from an inbred C57BL/6 background. Associated Publication: IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling
anti-Powassan virus antibodies and hybridoma cell linesVanBlargan, Laura ; Diamond, Michael
T-018559
— Murine anti-Powassan virus antibodies and hybridoma cell Publication: An mRNA Vaccine Protects Mice against Multiple Tick-Transmitted Flavivirus Infections
Plasmid pHLFcHis-Glycophorin ATolia, Niraj
T-018578
— Plasmid comprising the signal peptide and extracellular domain of human glycophorin A fused to antibody Fc domain and a his tag. This plasmid has been used to study malaria treatments. Publications:
Lactobacillus reuteri deltaAratCervantes-Barragan, Luisa ; Di Luccia, Blanda ; Caparon, Michael ; Colonna, Marco
T-018589
— Bacteria modified from the parental strain Lactobacillus reuteri 100-23 that doesn’t express the enzyme aryl aminotransferase. Culture supernatants from this bacterial strain failed to stimulate AhR reporter cells. Publication: Lactobacillus reuteri induces gut intraepithelial CD4+CD8α …
Bio-robotic “artificial nose” system for detecting explosives and other chemicalsTadepalli, Sirimuvva ; Traner, Michael ; Chandak, Rishabh ; Mehta, Darshit ; Saha, Debajit ; Singamaneni, Srikanth ; Chakrabartty, Shantanu ; Altan, Ege ; Raman, Baranidharan
T-019136
— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …
S1P1-targeted PET tracersYue, Xuyi ; Rosenberg, Adam ; Liu, Hui ; Tu, Zhude "Will"
T-016151
— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…