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Anti-Influenza HA monoclonal antibodiesEllebedy, Ali
T-019529
— Panel of 300 recombinant human monoclonal antibodies that are directed against influenza virus HA. These antibodies were derived from plasmablasts and germinal center B cells that were isolated from three healthy volunteers after influenza vaccination. Turner, J. S., Zhou, J. Q., Han, J., Schmitz, …
iPSC line AN1.1Neilson, Amber
T-019532
— AN1.1 is an iPSC line that was reprogrammed from healthy renal epithelial cells. Has proven easy to use for gene editing and efficient for differentiating into a number cell/tissue types. Whole genome sequencing data is available.
Mayaro virus monoclonal antibodies and hybridomasEarnest, James ; Diamond, Michael
T-019543
— Mayaro virus (MAYV) is an emerging mosquito-transmitted alphavirus. This is a panel of 18 neutralizing mAbs agains MAYV, 11 of which have activity that inhibited infection with EC50 values
Plasmids for calling cards and single cell calling cardsMoudgil, Arnav ; Wilkinson, Michael Nathaniel ; Lalli, Matthew ; Chen, Xuhua ; Mitra, Robi
T-019487
— These plasmids can be used for single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution (WUSTL Technology T-018069). scCC simultaneously maps the precise location of tran…
Inflammatory bowel disease biomarkers and therapeutic targetLiu, Ta-Chiang ; Kaiko, Gerard ; Stappenbeck, Thaddeus
T-017071
— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…
Automated image processing tools for quantitative SPECT and PET scansRahman, Md Ashequr ; Yu, Zitong ; Moon, Hae Sol ; Liu, Ziping ; Jha, Abhinav Kumar
T-019331
— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…
Low cost, versatile enzymatic synthesis of beta-lactone peptides for antibiotic or serine hydrolase inhibitor drug discoverySchaffer, Jason ; Reck, Margaret ; Wencewicz, Timothy
T-016508
— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…
Rapid, accurate RT-PCR test for enterovirus D68Wylie, Todd ; Wylie, Kristine ; Storch, Gregory
T-015155
— Technology Description A team of researchers at Washington University designed patented primers for a sensitive, specific, real-time reverse transcriptase PCR (RT-PCR) assay to quickly detect enterovirus D68 (EV-D68). EV-D68 is an emerging, highly contagious respiratory virus that can cause seve…
Monoclonal antibodies against pSer784-VCPShao, Jieya
T-019491
— VCP is an essential AAA+ ATPase that regulates proteostasis under normal and stressed cellular conditions. These monoclonal antibodies specifically recognize pSer784-VCP, which is phosphorylated during the DNA damage response and plays a crucial role in cellular survival upon genotoxic chemotherapy …
In vivo editing via targeted adenoviral vectorsCuriel, David
T-016332
— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…
Biological and Biochemical Production of Enantiopure L-Piperazic AcidHu, Yifei ; Van Dyke-Blodgett, Joshua
T-017073
— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…
In vivo editing via targeted adenoviral vectorsCuriel, David
— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…
Low-cost optical sensors for high performance, discrete hearing aidsLiao, Jie ; Yang, Lan
T-019167
— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…
Treatment for chronic migrainesZhang, Jintao ; Zhang, Zhiyu ; Hu, Rong ; Cloud, Megan ; Cao, Yu-Qing
T-018942
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…
Flag tagged BK(MDAL) in pBUD mchLorca, Ramon ; England, Sarah
T-019344
— Plasmid for flag tagged BK(MDAL) in a pBUD mcherry vector.
Artificial antibody platform to eliminate cold-chain in label-free plasmonic biosensor detection for diagnostics and researchLiu, Keng-Ku ; Morrissey, Jeremiah ; Tian, Limei ; Kharasch, Evan ; Abbas, Abdennour ; Singamaneni, Srikanth
T-013772
— Technology Description An interdisciplinary team of researchers at Washington University have developed a patented plasmonic nanotransducer system with built-in, highly stable artificial antibodies that can quickly detect and quantify biological molecules. These artificial antibodies can be rapidl…
Nanomaterial to eliminate cold chain by preserving biological reagents and patient samplesWang, Congzhou ; Morrissey, Jeremiah ; Kharasch, Evan ; Singamaneni, Srikanth
T-016668
— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…
Encapsulation to protect detection antibodies in implantable and wearable biosensorsMorrissey, Jeremiah ; Scheller, Erica ; Gupta, Rohit ; Luan, Jingyi ; Chakrabartty, Shantanu ; Singamaneni, Srikanth
T-019364
— Technology Description An interdisciplinary team of researchers at Washington University have developed a universal system designed to extend the lifetime of implantable and wearable biosensors by protecting detection antibodies from harsh conditions and enabling a refreshing process to release bo…
Mouse Anti-Human PLD3 (Phospholipase D3) antibody HJ16.6Holtzman, David
T-019280
— Anti-human hPLD3 antibody raised in mice. The antibody isotype is islgG2b.
Clifednamide compoundsYang, Jinping ; Van Dyke-Blodgett, Joshua ; Qi, Yunci ; Wencewicz, Timothy
T-019321
— Clifednamide A and C are congeners of long known ikarugamycin. Ikarugamycin has anti-inflammatory, anti-ciliate, plant modulatory and other desirable bioactivities. These clifednamide compounds may also have therapeutic, industrial or agricultural value. Publication: Qi, Y., Ding, E., & Blodget…