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SILTmass softwareBateman, Randall ; Elbert, Donald
T-008416
— Background Quantitation of relative or absolute amounts of proteins by mass spectrometry can be prone to large errors. The use of MS/MS ion intensities and stable isotope labeling, a method called isotope labeling tandem mass spectrometry (SILT), decreases the effects of contamination from unrelate…
Universal Targeted Drug Delivery and Imaging PlatformLi, Xuesong ; Li, Ruihan ; Delawder, Abigail "Abby" ; Barnes, Jonathan
T-018548
— Background Targeted delivery of cytotoxic therapeutics is crucial to prevent adverse side effects of chemotherapy and to increase drug concentrations at the tumor site. These prerequisites also apply to the treatment of infections caused by multiple drug resistant bacteria. To address this unmet n…
Reproducible High Yielding Cu-64 Radioisotope ManufacturingZerkel, Patrick ; Lawrence, Luke ; Gaehle, Gregory
T-018514
— Background: Its unique imaging characteristics and favorable half-life and decay properties make radioisotope copper-64 (Cu-64) most desirable for PET imaging. To meet the increasing demand, an efficient high yielding Cu-64 manufacturing process is essential. To address this unmet need, scientists f…
CellTags: Tracking Individual Cells during Cell ReprogrammingMorris, Samantha
T-018555
— Background Cell populations are quite heterogeneous yet are typically analyzed in bulk, masking unique behavioral features. This is particularly problematic in cell reprogramming, where in a given population of cells, only a small number complete reprogramming. Single-cell technologies address the …
Non-invasive Technology Enables Brain Tumor Biopsy Without SurgeryDunn, Gavin ; Petti, Allegra ; Chen, Hong ; Leuthardt, Eric
T-017113
— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…
Targeting CD5+ Dendritic Cell in Skin for the Treatment of Chronic DiseasesKlechevsky, Eynav
T-016609
— Background Dendritic cells (DCs) are antigen-presenting cells that are essential to the adaptability of the immune system. Several subsets of DCs have been identified in tissues that interface with the environment (e.g. skin, mucosal lining). While the role of specific DC subsets are unknown, DCs p…
Tools for the Detection of High-Density Lipoprotein Transport To and From TissuesZinselmeyer, Bernd ; Huang, Li-Hao ; Randolph, Gwendalyn
T-015939
— Background High-density lipoproteins (HDLs) have been widely studied and linked to various diseases, especially metabolic diseases. HDL levels in the blood have traditionally been used as a benchmark for risk of cardiovascular disease. However, these blood tests may be misleading – HDL levels…
MicroRNA-induced Direct Conversion of Human Adult Fibroblasts into NeuronsAbernathy, Daniel ; Yoo, Andrew
T-017136
— Background: Studying late-onset neurodegenerative disorders using patient-specific neurons is one of the primary goals of precision medicine. The ability to generate human neurons that mimic the neurons of elderly individuals will provide an instrumental platform to model and study adult-onset neuro…
Deforming Diagnostic to Radiotherapy Images for the Initial Treatment PlanMutic, Sasa ; Zhao, Tianyu
T-018603
— Background: Prior to undergoing radiation treatment, the patient is required to undergo a simulation scan. This involves positioning the patient body on a platform that resembles the radiotherapy machine couch. Then the scanning computerized tomography (CT) or magnetic resonance imaging (MRI) device…
Comfortable radiotherapy couch to improve precision and accuracyNo items found
— Background: High precision and accuracy is critically needed for the use of radiation treatment and diagnostic imaging (magnetic resonance imaging, computerized tomography, X-ray, positron emission tomography); each of these modalities uses the standard flat couch to manipulate the patient during pr…
Targeting hepatic arginine metabolism for treatment of metabolic diseasesMayer, Allyson ; Zhang, Yiming ; Higgins, Cassandra ; DeBosch, Brian
T-017417
— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…
Cochlear Fluids SimulatorSalt, Alec
T-018692
— Background: Local drug therapy of the inner ear became popular in the 1990s to treat a number of ear disorders. Local therapy allows the drug to bypass entry barriers, reducing systemic toxicities. For novel drugs to be delivered to the inner ear, pharmacokinetic (PK) values such as half-life and ma…
Spinning Spheres for Magnetic ResonanceAlbert, Brice ; Barnes, Alexander
T-017912
— Background: A commonly used approach for the analysis of the molecular structure, content, and purity of solid and liquid samples is magic angle spinning nuclear magnetic resonance (MAS NMR). This technique provides greater resolution to better identify and analyze chemical spectra compared to solid…
Anti-PDZ TIP1 Antibody Therapy for CancerYan, Heping ; Kapoor, Vaishali ; Hallahan, Dennis
T-017064
— Background: Lung cancer is one of the leading causes of cancer-related deaths worldwide. In the United States, it is second most common cancer for men and women and the leader for cancer-related death. Non-small-cell lung cancer (NSCLC) accounts for 85% of all reported lung cancer cases and is relat…
Targeting hepatic arginine metabolism for treatment of metabolic diseasesZhang, Yiming ; Mayer, Allyson ; Higgins, Cassandra ; DeBosch, Brian
T-017490
— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…
ID CUBE: Interactive Discovery CubeKim, David ; Mishra, Deependra ; Wu, Qian ; Zhang, Hairong ; Garnett, Roman ; Huang, Yunshen ; Du, Tommy ; Berezin, Mikhail
T-016317
— Background: With the advancement in the area of hyperspectral imaging technology, there is an influx of data being collected from disparate sources of highly sophisticated technology. Processing these data using current software is either non-interactive, in capable of leveraging the wealth of infor…
Insert device that enhances MR and PET image resolution for MR-PET machinesTai, Yuan-Chuan
T-007555
— Background PET-CT scanners have been widely used in the identification of tumors and localization for biopsies due to its superior ability to detect biochemical and physiological functions. However, one of the main limitations of PET-CT is the inability to visualize soft tissues, which may be impor…
Targeting B Cells for Antibody-Mediated Graft RejectionWang, Xiaoli ; Fremont, Daved ; Nelson, Christopher ; Edelson, Brian ; Liu, Chang
T-018682
— Disease Indications Drug type: Biologic – engineered protein Drug class: First in class Technology: A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …
Miniature, portable device for measuring exposure to airborne nanoparticlesQi, Chaolong ; Chen, Da-Ren
T-006838
— Technology Description Engineers in Prof. Daren Chen’s laboratory have developed a patented portable device for sampling and measuring nanoaerosols for industrial hygiene and aerosol science applications. Currently, a variety of industrial applications require the chemical synthesis of submi…
Washington University Profile System (WUPS)Komeshak, Rachel ; Lackey, Ian ; Kenney, Kenneth ; Hunstad, David ; Rich, Eliot
T-017287
— Background: Faculty members from institutions all over the world are publishing scientific articles, presenting data to conferences, and writing proposals for government-funded grants all simultaneously at one time. Of course, the outcomes happen to be known at different times for each specific task…