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Non-invasive Technology Enables Brain Tumor Biopsy Without SurgeryPetti, Allegra ; Dunn, Gavin ; Chen, Hong ; Leuthardt, Eric
T-017113
— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…
Styryl Heteroaromatic Ring Containing Analogues for Alpha-SynucleinYue, Xuyi ; Li, Junfeng ; Kotzbauer, Paul ; Tu, Zhude "Will"
T-014558
— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…
Nanomaterials for Imaging and Treatment of AmyloidosisLiu, Yongjian ; Guruswami, Sundaram ; Bieschke, Jan ; Sharma, Vijay
T-017876
— Background 8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…
Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)Sivapackiam, Jothilingam ; Guruswami, Sundaram ; Sharma, Vijay
T-016665
— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…
Targeting hepatic arginine metabolism for treatment of metabolic diseasesZhang, Yiming ; Mayer, Allyson ; Higgins, Cassandra ; DeBosch, Brian
T-017490
— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…
High-performance, nanoengineered two-phase cooling system for high powered electronicsShan, Li ; Ma, Binjian ; Agonafer, Damena
T-018032
— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …
Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive functionLuo, Zonghua ; Liu, Hui ; Jin, Hongjun ; Tu, Zhude "Will"
T-016517
— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…
Photoacoustic tomography of human brainMaslov, Konstantin ; Nie, Liming ; Cai, Xin ; Anastasio, Mark ; Wang, Lihong
T-013043
— This technology features a photon recycler to increase light transmittance through the human skull, a subtraction imaging method to image targets through human skull, and a filtering method to improve the contrast. Optical imaging is desirable because high functional hemoglobin contrast can be dire…
Grueneisen-memory photoacoustic microscopyZhang, Chi ; Wang, Lidai ; Wang, Lihong
T-014165
— Lihong Wang, Professor at Washington University in St. Louis, is a pioneer in the field of Photoacoustic (PA) Imaging. His innovations have enabled non-invasive imaging of living organisms at scales ranging from subcellular to whole-body at depths and resolutions that are simply impossible with any …
Immunohistochemical diagnosis of human renal chromophobe carcinomaGaut, Joseph ; Crimmins, Dan ; Ladenson, Jack
T-011164
— This novel immunohistochemical marker would be a valuable diagnostic aid to the practicing surgical pathologist who is confronted with this particular diagnostic challenge. Companies may license this antibody for clinical testing, or cases may be referred to Washington University for subspecialty c…
Polyclonal antibody for straining human Cytokeratin 13 (HuCK13)Ladenson, Jack
T-004395
— Rabbit polyclonal antibodies were generated using two distinct 20-mer synthetic peptides corresponding to the unique C-terminal extension of HuCKI 3 using standard protocols. Final purification used the corresponding peptide immunogen affinity column. Possible uses: histological detection in tumors …
Measurement of NT-ProBNP in human blood using a monoclonal antibodyLaterza, Omar ; Landt, Yvonne ; Ladenson, Jack
T-004030
— This is a monoclonal antibody specific for NT-Pro BNP and can be used singly in a competitive immunoassay to measure the amount of this analyte in blood samples for the purpose of diagnosis or monitoring of congestive heart failure. In addition, it could be used in a sandwich immunoassay with a mono…
Normothermic Extracorporal Liver Perfusion (NELP)Lin, Yiing ; Banan, Babak ; Chapman Sr., William
T-015492
— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…
Reversibly switchable photoacoustic tomography using a bacterial phytochrome as a genetically encoded near-infrared photochromic probeYao, Junjie ; Li, Lei ; Wang, Lihong
T-015670
— The invention is a novel photoacoustic imaging technique, termed reversibly switchable photoacoustic tomography (RS-PAT). It exhibits a large penetration depth, a high detection sensitivity, and a spatial super-resolution. The most important feature of this technique is that it significantly incre…
High resolution imaging using subwavelength grating structuresWang, Lihong ; Shen, Yuecheng ; Shen, Jung-Tsung
T-012856
— Conventional optics are generally restrained by a law of physics known as the diffraction limit, which dictates that optical systems can only resolve images down to about half the wavelength of the light used to produce the image (λ/2), or down to about 200 nanometers for most standard optics…
Chaotic Optomechanical ResonatorsYang, Lan ; Ozdemir, Sahin
T-016229
— Background: Chaos is considered hypersensitive to conditions of a system and is often thought to be unpredictable and difficult to explain. However, recent work has shown that chaos can be added as noise to improve amplification of weak signals through stochastic resonance. Stochastic resonance has …
Patient Access Scheduling SystemWhipple, Toni ; Melnek, Christine ; Reynolds, Steven ; Hughes, Scott ; Dodt, Jeremy ; Mantia, Jill
T-015846
— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…
Zuum – appCorcoran, Heather ; Colditz, Graham
T-011983
— Zuum is a health-risk assessment software that serves as a prognostic for various types of cancer.
Quit HelpersSumner, Walton ; Colditz, Graham ; McQueen, Amy
T-014916
— Quit Helpers is an interactive web-based tool to recommend pharmacotherapy to smokers based on medical and personal factors. Although general information about cessation aids is abundant, Quit Helpers automates the process of identifying a specific cessation aid or combination of aids for individua…
Pediatric Hematology-Oncology Roadmap BuilderLackey, Ian ; Drozda, Mandy ; Jones, Sally ; Brown, Robert ; Rich, Eliot
T-010823
— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …