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Bacterial and Mammalian Expression Vectors for Production of SARS-CoV ProteinsNelson, Christopher ; Zhao, Haiyan ; Harvey, Ian ; Dai, Yanan ; Fremont, Daved
T-019413
— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available. Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…
Ceramide profiling for blood-based predictive screening for cardiovascular disease, heart failure and deathPeterson, Linda ; Ory, Daniel ; Schaffer, Jean
T-014627
— Technology Description A team of researchers has developed a high throughput, FDA-compliant assay to predict coronary heart disease and mortality in the general population 6-10 years before the onset of disease. This fully validated two-dimensional liquid chromatography-tandem mass spectrometry (L…
Method to generate functionally mature, stem-cell derived, beta cellsVelazco-Cruz, Leonardo ; Millman, Jeffrey
T-019270
— Technology Description Researchers at Washington University in St. Louis have developed an improved method to differentiate stem-cells into functionally mature, insulin-secreting beta cells (SC-beta cells). Pancreatic beta cells play an important role in controlling blood glucose levels as they se…
miRNA mimics to treat metabolic diseaseGong, Yong-feng ; Hou, Jianghui
T-017930
— Disease indication: metabolic disorders including insulin resistance and diabetic nephropathy Drug format: chemically modified synthetic microRNA (miRNA) Drug class: first-in-class for metabolic disease Research stage and Preliminary data: Target: miR-29 mimics can increase the gene expressio…
PET tracer to diagnose kidney diseaseReichert, David ; Beeman, Scott ; Baldelomar, Edwin ; Bennett, Kevin
T-018902
— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…
PET tracer to diagnose kidney diseaseReichert, David ; Beeman, Scott ; Baldelomar, Edwin ; Bennett, Kevin
T-018902
— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…
Human monoclonal antibodies against SARS-CoV-2 nucleocapsid proteinEllebedy, Ali
T-019492
— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab
Rapid PEG-based drug delivery implant for local treatment of cervical cancerSun, Jennifer ; Schwarz, Julie ; Federico, Cinzia ; Azab, Abdel Kareem
T-019396
— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors. The current standard-of-care treatment regimen …
Mouse monoclonal antibodies against SARS-CoV-2 spike proteinVanBlargan, Laura ; Zhao, Haiyan ; Fremont, Daved ; Diamond, Michael
T-019470
— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…
Human monoclonal antibodies against SARS-CoV-2 spike proteinTurner, Jackson ; Mudd, Philip ; Schmitz, Aaron ; McIntire, Katherine ; Ellebedy, Ali
T-019454
— Species: Human Target: SARS-CoV-2 spike protein Applications: Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab Available Antibodies mAb name Ag 30.0000 10.0…
Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)Fremont, Daved ; Diamond, Michael ; Ellebedy, Ali
T-019438
— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …
Human monoclonal antibodies against SARS-CoV-2 nucleocapsid proteinEllebedy, Ali
T-019492
— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab
Adenovirus- human ACE2 transduction system to sensitize mice to SARS-CoV-2Hassan, Ahmed ; Diamond, Michael
T-019482
— Technology Description Researchers at Washington University in St. Louis have developed a method to sensitize commercially available laboratory mice to SARS-CoV-2 infection. SARS-CoV-2 is the cause of the coronavirus disease 2019 (COVID-19) pandemic that has had severe morbidity and mortality impa…
High Performance Direct Methanol and Direct Ethanol Fuel Cells with Microscale Bipolar InterfaceSankarasubramanian, Shrihari ; Ramani, Vijay ; Wang, Zhongyang
T-019124
— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a biopolar interface membrane to prevent fuel crossover and improve the performance of direct methanol and direct ethanol fuel cells (DMFC and DEFC). This membrane separator is designed to maintain a steep pH …
Liquid biopsy assay for personalized prostate cancer treatmentPachynski, Russell ; Maher, Christopher ; Chaudhuri, Aadel
T-019287
— Technology Description A team of researchers at Washington University has developed “EnhanceAR-Seq”, a circulating tumor DNA (ctDNA) assay that predicts which patients are at high risk for developing resistance to androgen receptor (AR)-directed treatment for metastatic prostate cancer…
Chimpanzee adenovirus-based vaccine for COVID-19No items found
T-019478
— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…
Chimpanzee adenovirus-based vaccine for COVID-19Hassan, Ahmed ; Dmitriev, Igor ; Diamond, Michael ; Curiel, David
T-019478
— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…
PET tracers for detection of early stage Alzheimer’s diseaseSivapackiam, Jothilingam ; Guruswami, Sundaram ; Sharma, Vijay
T-013525
— Technology Description Researchers at Washington University in St. Louis have developed PET radiotracers to image amyloid beta (A-beta) at early stages of Alzheimer’s Disease (AD). For AD treatment to be effective, it may have to be administered during the preclinical stage. As such, there i…
Novel Method and Device to Produce Fluorine-18 PET TracersNo items found
T-015970
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …
Novel Method and Device to Produce Fluorine-18 PET TracersZhou, Dong
T-019276
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …