Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides. Two murine monoclonal antibodies (mAb 6H3 and mAb 8A3) neutralize GelE in a dose-dependent manner and are able to block inflammation in a cell culture system.