Summaries by Inventor Zorumski, Charles

Use of ent-allopregnanolone to treat glaucoma
Covey, Douglas ; Izumi, Yukitoshi ; Zorumski, Charles
T-018940

— Technology Description Researchers from Washington University in St. Louis and colleagues have identified ent-allopregnanolone (ent-AlloP) as a potential therapeutic to treat glaucoma. Glaucoma, the leading cause of irreversible blindness, results from damage to the retinal ganglion cells (RGSs) t…

NMDA receptor modulator for neuroprotection after a stroke
Mennerick, Steven ; Sun, Min-Yu ; Taylor, Amanda ; Zorumski, Charles
T-016328

— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases Drug format – neurosteroid Drug class – drug repurposing (25-hydroxycholesterol) Research stage and Preliminary data: In vitro – The inventors demonstrated…

Novel Sulfated Neurosteroid Molecules for Treating Migraines and Pain
Covey, Douglas ; Evers, Alex ; Mennerick, Steven ; Zorumski, Charles
T-021437

— Published date: 5/23/2026 Value Proposition: Steroidal trifluoromethyl ketone modulators of GABA-A and NMDA receptors for treating migraine, headache, and pain. Technology Description Clinical and scientific experts in modulating GABA-A and NMDA receptors at Washington University in St. Louis…