Summaries by Inventor Yoo, Andrew

Antisense Oligo to Enhance Neuronal Survival in Huntington’s Disease
Oh, Youngmi ; Yoo, Andrew
T-020121

— Published Date: 5/14/2025 Value Proposition: Novel antisense oligonucleotide (ASO) directly targeting a microRNA-mediated mechanism responsible for autophagy reduction and neurodegeneration in Huntington’s disease (HD) improving patient outcomes in pre-HD subjects. Technology Description R…

MicroRNA-induced Direct Conversion of Human Adult Fibroblasts into Neurons
Abernathy, Daniel ; Yoo, Andrew
T-017136

— Background: Studying late-onset neurodegenerative disorders using patient-specific neurons is one of the primary goals of precision medicine. The ability to generate human neurons that mimic the neurons of elderly individuals will provide an instrumental platform to model and study adult-onset neuro…