Summaries by Inventor Whelan, Sean

VSV-BSL2 reporter of SARS CoV infection
Bloyet, Louis-Marie ; Whelan, Sean

— This VSV-SARS1 chimeric virus is a biosafety level 2 reporter of SARS COV 1 infection. It could be used to study shared mechanisms of neutralization by antibodies, selection of escape mutants and studies of viral entry.

VSV-SARS2-mutants to characterize antibody panels
Liu, Zhuoming ; Whelan, Sean

— This is a large panel of variants in the SARS-CoV-2 spike protein incorporated into a VSV-vector. These were largely selected as escape mutants to neutralizing antibodies or were designed to probe the function of circulating viral variants. These constructs can be used to screen antibodies and solub…

Recombinant VSV vector for COVID-19 vaccine or drug screening
Rothlauf, Paul ; Whelan, Sean

— Background: Recombinant vesicular stomatitis virus (VSV) has successfully been used to create a vaccine for Ebola virus that is currently on the market. Previously, Professor Sean Whelan and colleagues have exploited the VSV platform to create similar vectors for both SARS and MERS. Technology: The…


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