Summaries by Inventor Milbrandt, Jeffrey
DiAntonio, Aaron ; Milbrandt, Jeffrey
T-018728
— Crispr developed SARM1 Knockout Rat
Gfrα1FloxEGFP miceJain, Sanjay ; Milbrandt, Jeffrey
T-017997
— Using the Cre-deletor strain Hoxb7-Cre, Washington University researchers developed transgenic mice with loxP sites flanking the gene for the glial cell line-derived neurotrophic factor (GDNF) family receptor α1 (GFRα1), which is involved in kidney tissue development. These mice were the…
Modulation of the DLK/JNK Pathway as a Method for Inhibiting Axonal DegenerationDiAntonio, Aaron ; Milbrandt, Jeffrey ; Miller, Bradley ; Press, Craig
T-008422
— Background: Axonal degeneration is a feature commonly associated with many neuropathological conditions including response to injury, exposure to neurotoxins, hereditary neuropathies, glaucoma, and neurodegenerative diseases. The degenerative process is active when neuronal insults trigger a self-de…
Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseasesBuchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442
— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…
Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseasesBuchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442
— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…
A companion diagnostic to SARM1 inhibitors for neurodegenerative diseasesBloom, Adam ; DiAntonio, Aaron ; Mao, Xianrong ; Milbrandt, Jeffrey
T-019378
— Technology Description Researchers at Washington University, led by Jeffrey Milbrandt, have developed a companion diagnostic for SARM1 inhibitors that detects pathogenic variants of the SARM1 gene. Patients with one of several identified variants of SARM1 would respond well to SARM1 inhibitor thera…
New Strategy for Treatment of Neurodegenerative Diseases with AxonopathyDiAntonio, Aaron ; Geisler, Stefanie ; Mao, Xianrong ; Milbrandt, Jeffrey ; Summers, Daniel
T-017543
— Value Proposition: This invention uses a novel gene therapy that blocks the axon degeneration typical of neurodegenerative diseases. Technology Description Researchers at Washington University in St. Louis have developed a new strategy for treatment of neurodegenerative diseases with axonopathy…
